3'-Adenylic acid, N-benzoyl-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5'-O-[(4-methoxyphenyl )diphenylmethyl]-, mono(2-chlorophenyl) ester, compd. with N,N-diethylethanamine (1:1)

Base Information

Chemical Name:3'-Adenylic acid, N-benzoyl-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5'-O-[(4-methoxyphenyl )diphenylmethyl]-, mono(2-chlorophenyl) ester, compd. with N,N-diethylethanamine (1:1)
CAS No.:75082-92-7
Molecular Formula:C49H51ClN5O9PSi.C6H15N
Molecular Weight:1049.68
Hs Code.:

3'-Adenylic acid,
N-benzoyl-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5'-O-[(4-methoxyphenyl
)diphenylmethyl]-, mono(2-chlorophenyl) ester, compd. with
N,N-diethylethanamine (1:1)

Synonyms:

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Chemical Property of 3'-Adenylic acid, N-benzoyl-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5'-O-[(4-methoxyphenyl )diphenylmethyl]-, mono(2-chlorophenyl) ester, compd. with N,N-diethylethanamine (1:1)

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3'-Adenylic acid, N-benzoyl-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5'-O-[(4-methoxyphenyl )diphenylmethyl]-, mono(2-chlorophenyl) ester, compd. with N,N-diethylethanamine (1:1)

There total 4 articles about 3'-Adenylic acid, N-benzoyl-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5'-O-[(4-methoxyphenyl )diphenylmethyl]-, mono(2-chlorophenyl) ester, compd. with N,N-diethylethanamine (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 75085-66-4
N⁶-Benzoyl-2'-O-t-butyldimethylsilyl-5'-monomethoxytrityladenosin-3'-(β-cyanoaethyl)(o-chlorphenyl)phosphat

: 121-44-8
triethylamine

: 75082-92-7
Triaethylammonium-6-benzoyl-2'-O-(tert-butyldimethylsilyl)-5'-O-(4-methoxytrityl)adenosin-3'-(2-chlorphenyl)phosphat>

Guidance literature:: With water; In pyridine; for 1h;
DOI:10.1002/hlca.19810640548

Reference yield:

: 72351-28-1
2-chlorophenyl phosphordi(1H-1-[1,2,4]triazolide)

: 75082-92-7
Triaethylammonium-6-benzoyl-2'-O-(tert-butyldimethylsilyl)-5'-O-(4-methoxytrityl)adenosin-3'-(2-chlorphenyl)phosphat>

Guidance literature:: Multi-step reaction with 3 steps

1: N-methylimidazole / pyridine / 0.17 h / -20 °C

2: pyridine / 5 h / Ambient temperature

3: 96 percent / water / pyridine / 1 h

With 1-methyl-1H-imidazole; water; In pyridine;
DOI:10.1002/hlca.19810640548

Reference yield:

: [1,2,4]Triazol-1-yl-phosphonic acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-(tert-butyl-dimethyl-silanyloxy)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester

: 75082-92-7
Triaethylammonium-6-benzoyl-2'-O-(tert-butyldimethylsilyl)-5'-O-(4-methoxytrityl)adenosin-3'-(2-chlorphenyl)phosphat>

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 5 h / Ambient temperature

2: 96 percent / water / pyridine / 1 h

With water; In pyridine;
DOI:10.1002/hlca.19810640548