3'-Guanylic acid, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(tetrahydro-2H -pyran-2-yl)-, 4-chlorophenyl 5-chloro-8-quinolinyl ester

Base Information

Chemical Name:3'-Guanylic acid, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(tetrahydro-2H -pyran-2-yl)-, 4-chlorophenyl 5-chloro-8-quinolinyl ester
CAS No.:75933-82-3
Molecular Formula:C58H51Cl2N6O12P
Molecular Weight:1125.96
Hs Code.:

3'-Guanylic acid,
N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(tetrahydro-2H
-pyran-2-yl)-, 4-chlorophenyl 5-chloro-8-quinolinyl ester

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3'-Guanylic acid, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(tetrahydro-2H -pyran-2-yl)-, 4-chlorophenyl 5-chloro-8-quinolinyl ester

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of 3'-Guanylic acid, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(tetrahydro-2H -pyran-2-yl)-, 4-chlorophenyl 5-chloro-8-quinolinyl ester

There total 7 articles about 3'-Guanylic acid, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(tetrahydro-2H -pyran-2-yl)-, 4-chlorophenyl 5-chloro-8-quinolinyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 71933-62-5
5'-O-(dimethoxytrityl)-2'-O-(tetrahydropyranyl)-N²-benzoylguanosine

: 81366-72-5
4-chlorophenyl 5-chloro-8-quinolyl hydrogen phosphate

: 75933-82-3
5'-O-(dimethoxytrityl)-2'-O-(tetrahydropyranyl)-N⁴-benzoylguanosine-3'-(4-chlorophenyl 5-chloro-8-quinolyl-phosphate)

Guidance literature:: With 8-quinolinesulphonyl tetrazolide; In pyridine; for 2h;
DOI:10.1246/cl.1982.197

Reference yield:

: 77181-80-7
Phosphorochloridic acid 4-chloro-phenyl ester 5-chloro-quinolin-8-yl ester

: 75933-82-3
5'-O-(dimethoxytrityl)-2'-O-(tetrahydropyranyl)-N⁴-benzoylguanosine-3'-(4-chlorophenyl 5-chloro-8-quinolyl-phosphate)

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N

2: tetrahydrofuran / 0.25 h

3: aqueous pyridine

4: 90 percent / 8-quinolinesulfonyltetrazolide / pyridine / 2 h

With pyridine; 8-quinolinesulphonyl tetrazolide; triethylamine; In tetrahydrofuran; pyridine;
DOI:10.1246/cl.1982.197

Reference yield:

: 772-79-2
4-chlorophenylphosphorodichloridate

: 75933-82-3
5'-O-(dimethoxytrityl)-2'-O-(tetrahydropyranyl)-N⁴-benzoylguanosine-3'-(4-chlorophenyl 5-chloro-8-quinolyl-phosphate)

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / tetrahydrofuran / 1.) 30 min., -10 deg C; 2.) 45 min, RT;

2: Et₃N

3: tetrahydrofuran / 0.25 h

4: aqueous pyridine

5: 90 percent / 8-quinolinesulfonyltetrazolide / pyridine / 2 h

With pyridine; 8-quinolinesulphonyl tetrazolide; triethylamine; In tetrahydrofuran; pyridine;
DOI:10.1246/cl.1982.197