2-(3,4-Dimethoxyphenyl)lactic acid ethyl ester

Base Information

Chemical Name:2-(3,4-Dimethoxyphenyl)lactic acid ethyl ester
CAS No.:19261-07-5
Molecular Formula:C13H18O5
Molecular Weight:254.279
Hs Code.:
DSSTox Substance ID:DTXSID00276864,DTXSID30940925
Nikkaji Number:J41.587A
Mol file:19261-07-5.mol

Synonyms:ethyl 2-(3,4-dimethoxyphenyl)-2-hydroxypropanoate;19261-07-5;2-(3,4-Dimethoxyphenyl)lactic acid ethyl ester;Lactic acid, 2-(3,4-dimethoxyphenyl)-, ethyl ester;Ethyl 3',4'-dimethoxy-2-methylmadelate;22076-46-6;DTXSID00276864;DTXSID30940925;AKOS011496712;LS-87466;Mandelic acid, 3,4-dimethoxy-.alpha.-methyl-, ethyl ester;2-(3,4-Dimethoxyphenyl)-2-hydroxypropanoic acid ethyl ester

Suppliers and Price of 2-(3,4-Dimethoxyphenyl)lactic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
LACTIC ACID, 2-(3,4-DIMETHOXYPHENYL)-, ETHYL ESTER 95.00%
5MG
$ 501.82

Total 3 raw suppliers

Chemical Property of 2-(3,4-Dimethoxyphenyl)lactic acid ethyl ester

Chemical Property:

Vapor Pressure:5.46E-06mmHg at 25°C
Boiling Point:365.6°Cat760mmHg
Flash Point:132.6°C
PSA：64.99000
Density:1.147g/cm³
LogP:1.47440
XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:254.11542367
Heavy Atom Count:18
Complexity:281

Purity/Quality:

99% ^*data from raw suppliers

LACTIC ACID, 2-(3,4-DIMETHOXYPHENYL)-, ETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C(C)(C1=CC(=C(C=C1)OC)OC)O

Technology Process of 2-(3,4-Dimethoxyphenyl)lactic acid ethyl ester

There total 3 articles about 2-(3,4-Dimethoxyphenyl)lactic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 40233-98-5
3,4-dimethoxyphenylglyoxylic acid ethyl ester

: 544-97-8
dimethyl zinc(II)

: 19261-07-5
(R)-ethyl 2-(3,4-dimethoxyphenyl)-2-hydroxypropanoate

Guidance literature:: With triethyl borate; (1R,2R,4aS,7R,8aR,9aS)-2-isopropenyl-1-isopropyl-4,4,7-trimethyldecahydro-9-oxa-3a-azacyclopenta[b]naphthalen-1-ol; In toluene; at -35 ℃; for 90.5h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1002/chem.201102913

Reference yield:

: 40233-98-5
3,4-dimethoxyphenylglyoxylic acid ethyl ester

: 544-97-8
dimethyl zinc(II)

: (S)-2-(3,4-Dimethoxy-phenyl)-2-hydroxy-propionic acid ethyl ester

: 19261-07-5
(R)-ethyl 2-(3,4-dimethoxyphenyl)-2-hydroxypropanoate

Guidance literature:: (S)-Ph(OH)CCONHBn; In toluene; at 0 ℃; for 4h; Title compound not separated from byproducts;
DOI:10.1021/ol052997m

Reference yield:

: 89980-69-8
3,4-dimethoxyphenylmagnesium bromide

: 19261-07-5
(R)-ethyl 2-(3,4-dimethoxyphenyl)-2-hydroxypropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2: triethyl borate; (1R,2R,4aS,7R,8aR,9aS)-2-isopropenyl-1-isopropyl-4,4,7-trimethyldecahydro-9-oxa-3a-azacyclopenta[b]naphthalen-1-ol / toluene / 90.5 h / -35 °C / Inert atmosphere

With triethyl borate; (1R,2R,4aS,7R,8aR,9aS)-2-isopropenyl-1-isopropyl-4,4,7-trimethyldecahydro-9-oxa-3a-azacyclopenta[b]naphthalen-1-ol; In tetrahydrofuran; toluene;
DOI:10.1002/chem.201102913