40233-98-5

Basic information

• Product Name: ethyl 3,4-dimethoxyphenylglyoxylate
• Synonyms: ethyl 3,4-dimethoxyphenylglyoxylate;2-(3,4-Dimethoxyphenyl)glyoxylic acid ethyl ester;3,4-Dimethoxy-α-oxobenzeneacetic acid ethyl ester;Ethyl 2-(3,4-dimethoxyphenyl)-2-oxoacetate
• CAS NO: 40233-98-5
• Molecular Formula: C₁₂H₁₄O₅
• Molecular Weight: 238.23656
• EINECS: 254-852-5
• Mol File: 40233-98-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 355.1°Cat760mmHg
• Flash Point: 156.9°C
• Appearance: /
• Density: 1.159g/cm³
• Vapor Pressure: 3.2E-05mmHg at 25°C
• Refractive Index: 1.502
• CAS DataBase Reference: ethyl 3,4-dimethoxyphenylglyoxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3,4-dimethoxyphenylglyoxylate(40233-98-5)
• EPA Substance Registry System: ethyl 3,4-dimethoxyphenylglyoxylate(40233-98-5)

Safety Data

• Hazardous Substances Data: 40233-98-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H14O5/c1-4-17-12(14)11(13)8-5-6-9(15-2)10(7-8)16-3/h5-7H,4H2,1-3H3

Upstream product

• 91-16-7 1,2-dimethoxybenzene 
• 4755-77-5 Ethyl oxalyl chloride 
• 7446-70-0 aluminium trichloride 
• 98-95-3 nitrobenzene 
• 89980-69-8 3,4-dimethoxyphenylmagnesium bromide 
• 95-92-1 oxalic acid diethyl ester 
• 64-17-5 ethanol 
• 127172-22-9 1-(3,4-dimethoxyphenyl)-3-(dimethylamino)prop-2-en-1-one 
• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 
• 18066-68-7 ethyl 3,4-dimethoxyphenylacetate 

Downstream Products

• 32407-67-3 ethyl-2-(3,4-dimethoxyphenyl)-2-hydroxyacetate 
• 18066-68-7 ethyl 3,4-dimethoxyphenylacetate 
• 19261-07-5 (R)-ethyl 2-(3,4-dimethoxyphenyl)-2-hydroxypropanoate 
• 4732-70-1 3,4-dimethoxyphenylglyoxylic acid 
• 861160-26-1 (Z)-ethyl 2-(3,4-dimethoxyphenyl)-2-(methoxyimino)acetate 
• 1339804-88-4 (Z)-ethyl 2-(2-acetoxy-4,5-dimethoxyphenyl)-2-(methoxyimino)acetate 
• 113752-35-5 (3,4-dimethoxy-phenyl)-hydroxy-norborn-5-en-2-yl-acetic acid-(2-diethylamino-ethyl ester); hydrochloride 
• 101747-49-3 (3,4-dimethoxy-phenyl)-hydroxy-norborn-5-en-2-yl-acetic acid 
• 3152-27-0 bromo 3,4-dimethoxyphenylacetic acid ethyl ester 

Relevant articles and documents

Electrochemical two-electron oxygen reduction reaction (ORR) induced aerobic oxidation of α-diazoesters

Electrochemical oxygen reduction reaction (ORR) is a powerful tool for introducing oxygen functional groups in synthetic chemistry. However, compared with the well-developed one-electron oxygen reduction process, the applications of two-electron oxygen re

Ambient and aerobic carbon-carbon bond cleavage toward α-ketoester synthesis by transition-metal-free photocatalysis

The α-oxoesterification of the CC double bond in readily available enaminones enabling efficient synthesis of α-ketoesters is developed. The reactions showing general tolerance to the reactions of primary and secondary alcohols proceed well under air via Rose Bengal (RB)-based photocatalysis. Particularly, this mild synthetic method has been discovered to tolerate various polyhydroxylated substrates such as phenolic alcohol, diols and triols with an excellent selectivity of mono-oxoesterification. What is more noteworthy is that α-ketoester functionalized 16-dehydropregnenolone acetate resulting from the elaboration on a natural product has been obtained practically.

Highly homogeneous stereocontrolled construction of quaternary hydroxyesters by addition of dimethylzinc to α-ketoesters promoted by chiral perhydrobenzoxazines and B(OEt)3

A highly efficient enantioselective addition of Me2Zn to α-ketoesters, assisted by a chiral perhydro-1,3-benzoxazine ligand, is described. This novel catalytic system offers homogeneous elevated enantioselectivities in the preparation of α-hydroxyesters that bear a quaternary stereocenter, with a minor dependence on electronic and steric effects when aromatic, heteroaromatic, or aliphatic α-ketoesters are employed. The catalyst can be recovered and reused without loss of activity.