Methyl 2-(2-methoxy-2-oxoethyl)-1-methyl-1H-indole-3-carboxylate

Base Information

Chemical Name:Methyl 2-(2-methoxy-2-oxoethyl)-1-methyl-1H-indole-3-carboxylate
CAS No.:75996-84-8
Molecular Formula:C14H15NO4
Molecular Weight:261.277
Hs Code.:
DSSTox Substance ID:DTXSID30506202
Nikkaji Number:J350.887K
Wikidata:Q82361851

Synonyms:75996-84-8;DTXSID30506202;Methyl 2-(2-methoxy-2-oxoethyl)-1-methyl-1H-indole-3-carboxylate

Suppliers and Price of Methyl 2-(2-methoxy-2-oxoethyl)-1-methyl-1H-indole-3-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl 2-(2-methoxy-2-oxoethyl)-1-methyl-1H-indole-3-carboxylate

Chemical Property:

PSA：57.53000
LogP:1.68040
XLogP3:1.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:261.10010796
Heavy Atom Count:19
Complexity:357

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C2=CC=CC=C2C(=C1CC(=O)OC)C(=O)OC

Technology Process of Methyl 2-(2-methoxy-2-oxoethyl)-1-methyl-1H-indole-3-carboxylate

There total 1 articles about Methyl 2-(2-methoxy-2-oxoethyl)-1-methyl-1H-indole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1485-23-0
2-(N-methyl)indolylmethyl acetate

: 124-38-9,18923-20-1
carbon dioxide

: 18107-18-1
diazomethyl-trimethyl-silane

: 875-79-6
1,2-dimethylindole

: 108796-93-6
methyl 1-methyl-1H-indole-2-acetate

: 75996-84-8
methyl 2-(2-methoxy-2-oxoethyl)-1-methyl-1H-indole-3-carboxylate

Guidance literature:: 2-(N-methyl)indolylmethyl acetate; carbon dioxide; With bis(tributylphosphine)dichloropalladium(II); diethylzinc; In hexane; N,N-dimethyl-formamide; at 0 - 40 ℃; for 16h; under 760.051 Torr;

diazomethyl-trimethyl-silane; In methanol; diethyl ether; for 0.166667h;
DOI:10.1021/acs.orglett.8b03337

Reference yield:

: 75996-84-8
methyl 2-(2-methoxy-2-oxoethyl)-1-methyl-1H-indole-3-carboxylate

: 75996-93-9
3-p-chlorophenylsulphonylamino-2-(2-hydroxyethyl)-1-methylindole

Guidance literature:: Multi-step reaction with 6 steps

1: 16.1 g / KOH / ethanol; H₂O / 0.5 h / Heating

2: 13.7 g / acetic anhydride / 0.5 h / Heating

3: 17.4 g / Heating

4: 9.9 g / melting in vacuo (3 min), distillation

5: 88 percent / LiAlH₄ / diethyl ether / 1 h / Ambient temperature

6: 0.4 g / dimethylsulfoxide / 48 h

With potassium hydroxide; lithium aluminium tetrahydride; acetic anhydride; In diethyl ether; ethanol; water; dimethyl sulfoxide;

Reference yield:

: 75996-84-8
methyl 2-(2-methoxy-2-oxoethyl)-1-methyl-1H-indole-3-carboxylate

: methyl 2,5-dihydro-5-methyl-2-(3-nitrophenyl)-1-oxo-1H-pyrido[4,3-b]indole-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / methanol / 24 h / Heating

2: 98 percent / aq. HCl / methanol / 12 h / 20 °C

3: 100 percent / Na; MeOH / 24 h / 20 °C

With hydrogenchloride; methanol; sodium; In methanol;
DOI:10.1002/hlca.200690248