1-(2,5-Dimethoxyphenyl)-2-phenylethan-1-one

Base Information

Chemical Name:1-(2,5-Dimethoxyphenyl)-2-phenylethan-1-one
CAS No.:76246-92-9
Molecular Formula:C16H16O3
Molecular Weight:256.301
Hs Code.:
DSSTox Substance ID:DTXSID70510762
Nikkaji Number:J2.097.259I
Wikidata:Q82369224

Synonyms:76246-92-9;1-(2,5-Dimethoxyphenyl)-2-phenylethan-1-one;1-(2,5-DIMETHOXYPHENYL)-2-PHENYLETHANONE;SCHEMBL17637149;DTXSID70510762

Suppliers and Price of 1-(2,5-Dimethoxyphenyl)-2-phenylethan-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(2,5-Dimethoxyphenyl)-2-phenylethan-1-one

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:256.109944368
Heavy Atom Count:19
Complexity:284

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC(=C(C=C1)OC)C(=O)CC2=CC=CC=C2

Technology Process of 1-(2,5-Dimethoxyphenyl)-2-phenylethan-1-one

There total 8 articles about 1-(2,5-Dimethoxyphenyl)-2-phenylethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 103-80-0
phenylacetyl chloride

: 150-78-7
1,4-dimethoxybezene

: 76246-92-9
1-(2,5-dimethoxy)-2-phenyl-1-ethanone

Guidance literature:: With zinc oxide nanoparticles supported on polyaniline; at 20 ℃; for 0.166667h; Neat (no solvent);
DOI:10.1080/00397911.2010.540695

Reference yield: 41.0%

: 201230-82-2
carbon monoxide

: 107099-99-0
2,5-dimethoxyphenylboronic acid

: 100-44-7
benzyl chloride

: 43037-60-1
2-benzyl-1,4-dimethoxybenzene

: 76246-92-9
1-(2,5-dimethoxy)-2-phenyl-1-ethanone

Guidance literature:: With potassium phosphate; palladium diacetate; tricyclohexylphosphine; In water; at 80 ℃; for 20h; under 7500.75 Torr; Inert atmosphere;
DOI:10.1016/j.tetlet.2010.09.078

Reference yield:

: 2785-98-0
2,5-dimethoxybenzoic acid

: 76246-92-9
1-(2,5-dimethoxy)-2-phenyl-1-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

1.2: 1 h / 0 - 20 °C

2.1: tetrahydrofuran / 1 h / 0 °C

With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/acs.jmedchem.8b00921