3-(2-Chlorophenyl)-2-methylpyrido[2,3-d]pyrimidin-4(3H)-one

Base Information

Chemical Name:3-(2-Chlorophenyl)-2-methylpyrido[2,3-d]pyrimidin-4(3H)-one
CAS No.:76285-13-7
Molecular Formula:C₁₄H₁₀ClN₃O
Molecular Weight:271.706
Hs Code.:
DSSTox Substance ID:DTXSID60525426
Wikidata:Q82393013

Synonyms:76285-13-7;DTXSID60525426;3-(2-Chlorophenyl)-2-methylpyrido[2,3-d]pyrimidin-4(3H)-one

Suppliers and Price of 3-(2-Chlorophenyl)-2-methylpyrido[2,3-d]pyrimidin-4(3H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 3-(2-Chlorophenyl)-2-methylpyrido[2,3-d]pyrimidin-4(3H)-one

Chemical Property:

PSA：47.78000
LogP:2.74250
XLogP3:2.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:271.0512396
Heavy Atom Count:19
Complexity:398

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=NC2=C(C=CC=N2)C(=O)N1C3=CC=CC=C3Cl

Technology Process of 3-(2-Chlorophenyl)-2-methylpyrido[2,3-d]pyrimidin-4(3H)-one

There total 7 articles about 3-(2-Chlorophenyl)-2-methylpyrido[2,3-d]pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 3809-93-6
2-Methyl-4H-pyrido<2,3-d><3,1>oxazin-4-one

: 95-51-2
o-chloroaniline

: 76285-13-7
3-(2-chlorophenyl)-2-methyl-pyrido<2,3-d>pyrimidin-4(3H)-one

Guidance literature:: In toluene; for 8h; Heating;
DOI:10.1016/j.bmc.2004.07.068

Reference yield: 28.0%

: 17782-03-5
2-acetamidonicotinic acid

: 95-51-2
o-chloroaniline

: 76285-13-7
3-(2-chlorophenyl)-2-methyl-pyrido<2,3-d>pyrimidin-4(3H)-one

Guidance literature:: at 180 ℃; for 0.25h;
DOI:10.1007/BF00799933

Reference yield:

: 59-67-6
nicotinic acid

: 76285-13-7
3-(2-chlorophenyl)-2-methyl-pyrido<2,3-d>pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / 30percent H₂O₂ / acetic acid / 3 h / 90 °C

2: PCl₅, POCl₃

3: 60 percent / conc. NH₄OH / 20 h / 155 °C

4: 70 percent / 4 h / 110 °C

5: POCl₃ / toluene / Heating

With ammonium hydroxide; phosphorus pentachloride; dihydrogen peroxide; trichlorophosphate; In acetic acid; toluene;