2-Butylquinoline

Base Information

• Chemical Name: 2-Butylquinoline
• CAS No.: 7661-39-4
• Molecular Formula: C13H15N
• Molecular Weight: 185.269
• Mol file: 7661-39-4.mol

Synonyms:Quinoline, 2-butyl-;2-Butyl-chinolin;2-butyl-quinoline;Quinoline,2-butyl;2-n-Butylquinoline;

Chemical Property of 2-Butylquinoline

Chemical Property:

• Refractive Index: 1.5699
• Boiling Point: 304.5°C (estimate)
• PSA: 12.89000
• Density: 1.0030
• LogP: 3.57740

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 2-Butylquinoline

There total 8 articles about 2-Butylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-Chloroquinoline (612-62-4) + butylboronic acid (4426-47-5) → 2-n-butylquinoline (7661-39-4) + 2,2'-biquinoline (119-91-5)

Guidance literature:

With potassium carbonate; bis(η3-allyl-μ-chloropalladium(II)); (1RS,2RS,3SR,4SR)-1,2,3,4-tetrakis((diphenylphosphanyl)methyl)cyclopentane; In xylene; at 130 ℃; for 20h;

DOI:10.1016/j.tet.2004.03.009

Reference yield:

quinoline (91-22-5) + valeric acid (109-52-4) → 1-butylene (106-98-9,9003-28-5) + 2-n-butylquinoline (7661-39-4) + 4-n-butylquinoline (74808-78-9)

Guidance literature:

With dipotassium peroxodisulfate; sulfuric acid; copper diacetate; In water; at 57 ℃; for 3h; Rate constant; Product distribution; (NH₄)2S₂O₈ for K₂S₂O₈;

DOI:10.1021/jo01311a039

Reference yield:

quinoline (91-22-5) + Dimethyldisulphide (624-92-0) → 2-(methylthio)quinoline (40279-26-3) + 2-n-butylquinoline (7661-39-4)

Guidance literature:

With n-butyllithium; 2-(N,N-dimethylamino)ethanol; 1.) hexane, -78 deg C, 30 min, 2.) Et₂O, -78 deg C, 1 h;

DOI:10.1039/a705027e

upstream raw materials:

2-ethoxyquinoline

n-butyllithium

diethyl ether

quinoline

Downstream raw materials:

2-methylquinoline

propene

2-quinolone methide

Refernces

• 1、 Gros, Philippe,Fort, Yves,Caubere, Paul. "Aggregative activation in heterocyclic chemistry. Part 5. Lithiation of pyridine and quinoline with the complex base BuLi·Me2N(CH2)2OLi (BuLi·LiDMAE)". . p. 3597 - 3600. Retrieved 2007/10/03.