trans-4-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}cyclo-hexylamine

Base Information

Chemical Name:trans-4-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}cyclo-hexylamine
CAS No.:775281-23-7
Molecular Formula:C₁₉H₂₈F₃N₃
Molecular Weight:355.447
Hs Code.:

Synonyms:trans-4-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}cyclo-hexylamine

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Chemical Property of trans-4-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}cyclo-hexylamine

Chemical Property:

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Technology Process of trans-4-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}cyclo-hexylamine

There total 5 articles about trans-4-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}cyclo-hexylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1000044-45-0
4-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}cyclohexanone

: 775281-23-7
trans-4-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}cyclo-hexylamine

: cis-4-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}cyclo-hexylamine

Guidance literature:: With ammonium acetate; sodium cyanoborohydride; In methanol; for 3h; Heating / reflux;

Reference yield:

: 76835-14-8
1-[3-(trifluoromethyl)phenyl]piperazine hydrochloride

: 775281-23-7
trans-4-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}cyclo-hexylamine

: cis-4-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}cyclo-hexylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetonitrile / Heating / reflux

2.1: hydrogenchloride / methanol; water / 20 °C

2.2: pH 10

3.1: ammonium acetate; sodium cyanoborohydride / methanol / 3 h / Heating / reflux

With hydrogenchloride; ammonium acetate; sodium cyanoborohydride; potassium carbonate; In methanol; water; acetonitrile;

Reference yield:

: 1000044-44-9
1-[2-(1,4-dioxaspiro[4.5]dec-8-yl)ethyl]-4-(3-trifluoromethylphenyl)piperazine

: 775281-23-7
trans-4-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}cyclo-hexylamine

: cis-4-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}cyclo-hexylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / methanol; water / 20 °C

1.2: pH 10

2.1: ammonium acetate; sodium cyanoborohydride / methanol / 3 h / Heating / reflux

With hydrogenchloride; ammonium acetate; sodium cyanoborohydride; In methanol; water;