1-[2-(1,4-dioxaspiro[4.5]dec-8-yl)ethyl]-4-(3-trifluoromethylphenyl)piperazine

Base Information

Chemical Name:1-[2-(1,4-dioxaspiro[4.5]dec-8-yl)ethyl]-4-(3-trifluoromethylphenyl)piperazine
CAS No.:1000044-44-9
Molecular Formula:C₂₁H₂₉F₃N₂O₂
Molecular Weight:398.469
Hs Code.:

Synonyms:1-[2-(1,4-dioxaspiro[4.5]dec-8-yl)ethyl]-4-(3-trifluoromethylphenyl)piperazine

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Chemical Property of 1-[2-(1,4-dioxaspiro[4.5]dec-8-yl)ethyl]-4-(3-trifluoromethylphenyl)piperazine

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Technology Process of 1-[2-(1,4-dioxaspiro[4.5]dec-8-yl)ethyl]-4-(3-trifluoromethylphenyl)piperazine

There total 3 articles about 1-[2-(1,4-dioxaspiro[4.5]dec-8-yl)ethyl]-4-(3-trifluoromethylphenyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 171361-59-4
2-(1,4-dioxaspiro[4.5]decan-8-yl)ethyl methanesulfonate

: 76835-14-8
1-[3-(trifluoromethyl)phenyl]piperazine hydrochloride

: 1000044-44-9
1-[2-(1,4-dioxaspiro[4.5]dec-8-yl)ethyl]-4-(3-trifluoromethylphenyl)piperazine

Guidance literature:: With potassium carbonate; In acetonitrile; Product distribution / selectivity; Heating / reflux;

Reference yield: 74.0%

: 1000044-42-7
2-(1,4-dioxaspiro[4.5]dec-8-yl)-1-[4-(3-trifluoromethylphenyl)-piperazin-1-yl]ethanone

: 1000044-44-9
1-[2-(1,4-dioxaspiro[4.5]dec-8-yl)ethyl]-4-(3-trifluoromethylphenyl)piperazine

Guidance literature:: 2-(1,4-dioxaspiro[4.5]dec-8-yl)-1-[4-(3-trifluoromethylphenyl)-piperazin-1-yl]ethanone; With lithium aluminium tetrahydride; In diethyl ether; at 10 - 20 ℃;

With sodium hydroxide; In water; at 0 - 20 ℃; for 0.25h; Product distribution / selectivity;

Reference yield:

: 76835-14-8
1-[3-(trifluoromethyl)phenyl]piperazine hydrochloride

: 1000044-44-9
1-[2-(1,4-dioxaspiro[4.5]dec-8-yl)ethyl]-4-(3-trifluoromethylphenyl)piperazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.17 h

1.2: 20 °C

2.1: lithium aluminium tetrahydride / diethyl ether / 10 - 20 °C

2.2: 0.25 h / 0 - 20 °C

With lithium aluminium tetrahydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In diethyl ether; dichloromethane;