(alpha-Chlorobenzyl)diphenylphosphine oxide

Base Information

• Chemical Name: (alpha-Chlorobenzyl)diphenylphosphine oxide
• CAS No.: 7751-69-1
• Molecular Formula: C19H16ClOP
• Molecular Weight: 326.762
• DSSTox Substance ID: DTXSID601260566
• Nikkaji Number: J1.818.304H
• Mol file: 7751-69-1.mol

Synonyms:DTXSID601260566;(alpha-Chlorobenzyl)diphenylphosphine oxide;(Chlorophenylmethyl)diphenylphosphine oxide;7751-69-1

Chemical Property of (alpha-Chlorobenzyl)diphenylphosphine oxide

Chemical Property:

• XLogP3: 4.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 326.0627298
• Heavy Atom Count: 22
• Complexity: 357

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(P(=O)(C2=CC=CC=C2)C3=CC=CC=C3)Cl

Technology Process of (alpha-Chlorobenzyl)diphenylphosphine oxide

There total 8 articles about (alpha-Chlorobenzyl)diphenylphosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

benzaldehyde (100-52-7) + chloro-diphenylphosphine (1079-66-9,74391-44-9) → α-chlorobenzyl(diphenyl)phosphine oxide (7751-69-1)

Guidance literature:

at 180 ℃; for 10h;

DOI:10.1039/P19810000776

Reference yield:

benzylidene dichloride (98-87-3) + bis-(α-diphenylphosphinoyl-benzyl)-ether (64436-23-3) → benzyldiphenylphosphine oxide (2959-74-2) + α-chlorobenzyl(diphenyl)phosphine oxide (7751-69-1) + benzaldehyde (100-52-7)

Guidance literature:

With hydrogenchloride; In chloroform-d1; at 190 ℃; for 15h; Title compound not separated from byproducts;

DOI:10.1039/P19810000776

Reference yield:

benzaldehyde (100-52-7) + chloro-diphenylphosphine (1079-66-9,74391-44-9) → benzylidene dichloride (98-87-3) + bis-(α-diphenylphosphinoyl-benzyl)-ether (64436-23-3) + α-chlorobenzyl(diphenyl)phosphine oxide (7751-69-1) + <α-(α-chlorobenzyloxy)benzyl>diphenylphosphine oxide (64436-24-4)

Guidance literature:

at 50 - 100 ℃; Product distribution; Mechanism; reactions of chlorophosphines with aldehydes, various temperature and reaction times;

DOI:10.1039/P19810000776

upstream raw materials:

(diphenylphosphinyl)phenyldiazomethane

benzaldehyde

chloro-diphenylphosphine

benzylidene dichloride

Downstream raw materials:

trans-3,4,5-trimethoxystilbene

(E)-2-methoxystilbene

E-1-methyl-4-styryl-benzene

(E)-1-methyl-2-styryl-benzene