2-(Difluoromethoxy)benzyl bromide

Base Information

Chemical Name:2-(Difluoromethoxy)benzyl bromide
CAS No.:85684-64-6
Molecular Formula:C8H7 Br F2 O
Molecular Weight:237.044
Hs Code.:2909309090
European Community (EC) Number:671-880-7
DSSTox Substance ID:DTXSID90371756
Wikidata:Q72463274
Mol file:85684-64-6.mol

Synonyms:2-(Difluoromethoxy)benzyl bromide;85684-64-6;1-(bromomethyl)-2-(difluoromethoxy)benzene;2-difluoromethoxybenzyl bromide;Benzene, 1-(bromomethyl)-2-(difluoromethoxy)-;SCHEMBL584655;DTXSID90371756;a-Bromo-o-(difluoromethoxy)toluene;2-(Difluoromethoxy)-benzyl bromide;2-DIFLUOROMETHOXYBENZYLBROMIDE;CL8702;MFCD00190103;1-bromomethyl-2-difluoromethoxybenzene;AKOS005207097;PS-9972;CS-0030473;FT-0608781;EN300-80433;1-[bis(fluoranyl)methoxy]-2-(bromomethyl)benzene;A841406

Suppliers and Price of 2-(Difluoromethoxy)benzyl bromide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-(Difluoromethoxy)benzylbromide
1g
$ 55.00

SynQuest Laboratories
2-(Difluoromethoxy)benzyl bromide 98%
100 g
$ 570.00

SynQuest Laboratories
2-(Difluoromethoxy)benzyl bromide 98%
25 g
$ 181.00

SynQuest Laboratories
2-(Difluoromethoxy)benzyl bromide 98%
5 g
$ 52.00

Matrix Scientific
2-(Difluoromethoxy)benzyl bromide
25g
$ 185.00

Matrix Scientific
2-(Difluoromethoxy)benzyl bromide
5g
$ 50.00

Biosynth Carbosynth
2-(Difluoromethoxy)benzyl bromide
100 g
$ 780.00

Biosynth Carbosynth
2-(Difluoromethoxy)benzyl bromide
50 g
$ 480.00

Biosynth Carbosynth
2-(Difluoromethoxy)benzyl bromide
25 g
$ 282.50

Biosynth Carbosynth
2-(Difluoromethoxy)benzyl bromide
10 g
$ 136.00

Total 46 raw suppliers

Chemical Property of 2-(Difluoromethoxy)benzyl bromide

Chemical Property:

Appearance/Colour:clear, colorless to pale yellow liquid
Vapor Pressure:0.131mmHg at 25°C
Refractive Index:1.518
Boiling Point:225.2 °C at 760 mmHg
Flash Point:108.9 °C
PSA：9.23000
Density:1.537 g/cm³
LogP:3.18290
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
Sensitive.:Lachrymatory
Water Solubility.:Immiscible with water.
XLogP3:3.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:235.96483
Heavy Atom Count:12
Complexity:132

Purity/Quality:

97% ^*data from raw suppliers

2-(Difluoromethoxy)benzylbromide ^*data from reagent suppliers

Safty Information:

Pictogram(s): R34:Causes burns.; R36:Irritating to eyes.;
Hazard Codes:C
Statements: 34-36/37/38-40
Safety Statements: 24/25-26-36/37/39-45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C(=C1)CBr)OC(F)F
Uses 2-(Difluoromethoxy)benzyl bromide is used as a building block in organic synthesis. It also serves as a coupling reagent and N-protecting reagent. Further, it is used as a gas chromatography derivatizing agent.

Technology Process of 2-(Difluoromethoxy)benzyl bromide

There total 3 articles about 2-(Difluoromethoxy)benzyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 72768-94-6
2-(difluoromethoxy)benzyl alcohol

: 85684-64-6
1-(bromomethyl)-2-(difluoromethoxy)-benzene

Guidance literature:: With phosphorus tribromide; In diethyl ether; at 0 - 20 ℃; for 3h;
DOI:10.1002/ejoc.201601608

Reference yield:

: 42173-52-4
difluoromethyl 2-methylphenyl ether

: 85684-64-6
1-(bromomethyl)-2-(difluoromethoxy)-benzene

Guidance literature:: difluoromethyl 2-methylphenyl ether; With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 12h; Reflux;

With sodium sulfite; In water;
DOI:10.1002/ejoc.201601608

Reference yield:

: 71653-64-0
o-difluoromethoxybenzaldehyde

: 85684-64-6
1-(bromomethyl)-2-(difluoromethoxy)-benzene

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate; methanol / 0.17 h / 0 °C

2: phosphorus tribromide / diethyl ether / 3 h / 0 - 20 °C

With methanol; sodium tetrahydroborate; phosphorus tribromide; In diethyl ether;
DOI:10.1002/ejoc.201601608