5-(4-Methoxyphenyl)imidazolidine-2,4-dione

Base Information

• Chemical Name: 5-(4-Methoxyphenyl)imidazolidine-2,4-dione
• CAS No.: 6617-78-3
• Molecular Formula: C10H10 N2 O3
• Molecular Weight: 206.201
• Hs Code.: 2933990090
• NSC Number: 101479
• DSSTox Substance ID: DTXSID00295358
• Nikkaji Number: J26.385K
• Mol file: 6617-78-3.mol

Synonyms:5-(4-methoxyphenyl)imidazolidine-2,4-dione;6617-78-3;5-(4-METHOXYPHENYL)HYDATOIN;MFCD00219347;NSC101479;NCIOpen2_006823;Oprea1_029350;Oprea1_119764;5-(p-methoxyphenyl)hydantoin;5-(4-METHOXYPHENYL)-2,4-IMIDAZOLIDINEDIONE;SCHEMBL7167696;DTXSID00295358;DXCSOTJUBCFLRJ-UHFFFAOYSA-N;AC7710;BHS100780;STK285754;AKOS000545370;AKOS016050335;AB04930;CCG-108246;NSC-101479;SY016740;CS-0302942;FT-0709316;5-(4-methoxyphenyl)-imidazolidine-2,4-dione;A913781;Z56885773;5-(4-METHOXYPHENYL)-1H-IMIDAZOLE-2,4(3H,5H)-DIONE

Chemical Property of 5-(4-Methoxyphenyl)imidazolidine-2,4-dione

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 67.43000
• Density: 1.273g/cm³
• LogP: 1.23330
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 206.06914219
• Heavy Atom Count: 15
• Complexity: 272

Purity/Quality:

97% ^*data from raw suppliers

5-(4-Methoxyphenyl)imidazolidine-2,4-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2C(=O)NC(=O)N2

Technology Process of 5-(4-Methoxyphenyl)imidazolidine-2,4-dione

There total 19 articles about 5-(4-Methoxyphenyl)imidazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

potassium cyanide + ammonium carbonate (506-87-6,6721-33-1,10361-29-2) + 4-methoxy-benzaldehyde (123-11-5) → 5-(4-methoxyphenyl)imidazolidone-2,4-dione (6617-78-3)

Guidance literature:

With iron(III) oxide; In neat (no solvent); at 70 ℃; for 0.383333h;

DOI:10.1016/j.crci.2013.06.005

Reference yield: 86.1%

potassium cyanide (151-50-8) + ammonium carbonate (506-87-6,6721-33-1,10361-29-2) + 4-methoxy-benzaldehyde (123-11-5) → 5-(4-methoxyphenyl)imidazolidone-2,4-dione (6617-78-3)

Guidance literature:

In ethanol; water; at 60 ℃; for 12h;

DOI:10.1016/0223-5234(96)88263-8

Reference yield: 69.0%

2-[(4-methoxyphenyl)-2-ureido]acetamide → 5-(4-methoxyphenyl)imidazolidone-2,4-dione (6617-78-3)

Guidance literature:

With hydrogenchloride; In water; for 1h; Reflux;

DOI:10.1016/j.tet.2020.131340

upstream raw materials:

ethoxycarbonylamino-(4-methoxy-phenyl)-acetic acid amide

potassium cyanide

ammonium carbonate

4-methoxy-benzaldehyde

Downstream raw materials:

5-cyclohexyl-hydantoin

2-(4-methoxyphenyl)glycine

Methoxycarbonylamino-(4-methoxy-phenyl)-acetic acid

DL-α-Benzyloxycarbonylamino-(4-methoxy-phenyl)-essigsaeure