3-Chloro-5-hydroxy-4-methoxybenzoic acid

Base Information

Chemical Name:3-Chloro-5-hydroxy-4-methoxybenzoic acid
CAS No.:80547-63-3
Molecular Formula:C8H7ClO4
Molecular Weight:202.594
Hs Code.:
ChEMBL ID:CHEMBL327180
DSSTox Substance ID:DTXSID50513190
Wikidata:Q82372855

Synonyms:3-chloro-5-hydroxy-4-methoxybenzoic acid;CHEMBL327180;80547-63-3;DTXSID50513190;BDBM50405319

Suppliers and Price of 3-Chloro-5-hydroxy-4-methoxybenzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 3-Chloro-5-hydroxy-4-methoxybenzoic acid

Chemical Property:

XLogP3:2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:202.0032864
Heavy Atom Count:13
Complexity:197

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C=C1Cl)C(=O)O)O

Technology Process of 3-Chloro-5-hydroxy-4-methoxybenzoic acid

There total 3 articles about 3-Chloro-5-hydroxy-4-methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 54246-06-9
3-chloro-5-hydroxy-4-methoxybenzaldehyde

: 80547-63-3
3-chloro-5-hydroxy-4-methoxybenzoic acid

Guidance literature:: With sodium hydroxide; silver nitrate; at 55 ℃; for 0.25h;
DOI:10.1021/jm00345a012

Reference yield:

: 80547-69-9
3-hydroxy-4-methoxy-5-nitrobenzaldehyde

: 80547-63-3
3-chloro-5-hydroxy-4-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: stannous chloride, conc. HCl / 0 - 65 °C

2: 1.) 23percent NaNO₂, CuCl / 1.) H₂O, from 0 to 5 deg C, 1.5 h, 2.) H₂O, from 75 deg C to RT, overnight

3: 50 percent / AgNO₃, aq. NaOH / 0.25 h / 55 °C

With hydrogenchloride; sodium hydroxide; silver nitrate; copper(l) chloride; tin(ll) chloride; sodium nitrite;
DOI:10.1021/jm00345a012

Reference yield:

: 343867-62-9
3-Amino-5-hydroxy-4-methoxy-benzaldehyde

: 80547-63-3
3-chloro-5-hydroxy-4-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) 23percent NaNO₂, CuCl / 1.) H₂O, from 0 to 5 deg C, 1.5 h, 2.) H₂O, from 75 deg C to RT, overnight

2: 50 percent / AgNO₃, aq. NaOH / 0.25 h / 55 °C

With sodium hydroxide; silver nitrate; copper(l) chloride; sodium nitrite;
DOI:10.1021/jm00345a012