54246-06-9

Usage

Synthesis Reference(s)

Journal of Medicinal Chemistry, 25, p. 258, 1982 DOI: 10.1021/jm00345a012

Upstream product

• 343867-62-9 3-Amino-5-hydroxy-4-methoxy-benzaldehyde 
• 511295-05-9 5-chloro-O-acetyl isovanilline 
• 621-59-0 isovanillin 
• 881-57-2 isovanillin acetate 
• 80547-69-9 3-hydroxy-4-methoxy-5-nitrobenzaldehyde 

Downstream Products

• 34098-18-5 5-chloro-3,4-dihydroxybenzaldehyde 
• 511295-15-1 5'-chloro-2'-[2-(3'-chloro-5'-[1,3]dioxan-2-yl-6,2'-dimethoxy-biphenyl-3-yl)-ethyl]-2,4'-dimethoxy-biphenyl-4-carboxylic acid methyl ester 
• 511295-14-0 2'-[2-(3'-chloro-5'-[1,3]dioxan-2-yl-6,2'-dimethoxy-biphenyl-3-yl)-ethyl]-2,4'-dimethoxy-biphenyl-4-carboxylic acid methyl ester 
• 511295-18-4 5-chloro-5'-[2-(5-chloro-4'-hydroxymethyl-4,2'-dimethoxy-biphenyl-2-yl)-ethyl]-6,2'-dimethoxy-biphenyl-3-carbaldehyde 
• 511295-17-3 5-chloro-5'-[2-(4'-hydroxymethyl-4,2'-dimethoxy-biphenyl-2-yl)-ethyl]-6,2'-dimethoxy-biphenyl-3-carbaldehyde 
• 511295-24-2 5-Chloro-5'-[2-(4'-formyl-4,2'-dimethoxy-biphenyl-2-yl)-ethyl]-6,2'-dimethoxy-biphenyl-3-carbaldehyde 
• 511295-06-0 3-chloro-5-(1,3-dioxan-2-yl)-2-methoxyphenyl trifluoromethane sulfonate 
• 511295-25-3 3-chloro-5-[1,3]dioxan-2-yl-2-methoxy-phenol 
• 80547-63-3 3-chloro-5-hydroxy-4-methoxybenzoic acid 

Relevant academic research and scientific papers

Synthesis and antitumor activity of feruloyl and caffeoyl derivatives This paper is dedicated to Prof. Wei-xiao Hu for his lifelong commitment to mentoring graduate students

We developed two efficient protocols for the synthesis of feruloyl and caffeoyl derivatives from commercial vanillin and veratraldehyde. Pharmacological activities were assessed against a panel of human cancer cell lines in vitro. Most synthesized compounds demonstrated attractive cytotoxicity. Several new compounds demonstrated significant antiproliferative and cytotoxic activities against HeLa and Bewo tumor cell lines. In particular, 5-nitro caffeic adamantyl ester showed broad spectrum of tumor inhibition in 10 cell lines, and reduced tumor weight by 36.7% in vivo when administered at a dose of 40 mg kg-1.

Syntheses of chlorinated bisbibenzyls from bryophytes

Chlorinated bisbibenzyls of the isoplagiochin type detected in different bryophyte species were synthesized by an efficient and flexible unit construction system making extensive use of Suzuki and Wittig protocols.