Chemical Property of Luotonin A
Chemical Property:
- Melting Point:283-285 °C
- Boiling Point:530.9±60.0 °C(Predicted)
- PKA:1.61±0.20(Predicted)
- PSA：47.78000
- Density:1.44±0.1 g/cm3(Predicted)
- LogP:2.97340
- Solubility.:≤3mg/ml in DMSO;3mg/ml in dimethyl formamide
- XLogP3:2.7
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:0
- Exact Mass:285.090211983
- Heavy Atom Count:22
- Complexity:517
- Purity/Quality:
-
≥98% *data from raw suppliers
LuotonineA *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:C1C2=CC3=CC=CC=C3N=C2C4=NC5=CC=CC=C5C(=O)N41
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Description
Luotonin A is an alkaloid originally isolated from a plant used in traditional Chinese medicine. It inhibits the growth of mouse leukemia P388 cells (IC50 = 1.8 μg/ml). Luotonin A is structurally similar to the alkaloid camptothecin and, like camptothecin, it binds to and stabilizes the topoisomerase I-DNA binary complex, leading to DNA breakage and cell death (IC50 = 5.07-12.6 μM). Also like camptothecin, luotonin A forms non-covalent complexes with double-stranded DNA in the minor groove and this association can be followed by native fluorescence associated with the aromatic and heterocyclic ring structure. Luotonin A also selectively inhibits the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2 (IC50 = ~6 μM for each) in human liver microsomes.
