4-ETHOXY-3-METHOXYBENZONITRILE

Base Information

• Chemical Name: 4-ETHOXY-3-METHOXYBENZONITRILE
• CAS No.: 81259-56-5
• Molecular Formula: C10H11NO2
• Molecular Weight: 177.203
• Mol file: 81259-56-5.mol

Synonyms:4-ethoxy-3-methoxy-benzonitrile;4-Aethoxy-3-methoxy-benzonitril;3-Methoxy-4-aethoxy-benzoesaeure-nitril;

Chemical Property of 4-ETHOXY-3-METHOXYBENZONITRILE

Chemical Property:

• PSA: 42.25000
• LogP: 1.96558

Purity/Quality:

95% ^*data from raw suppliers

4-ETHOXY-3-METHOXY-BENZONITRILE ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-ETHOXY-3-METHOXYBENZONITRILE

There total 15 articles about 4-ETHOXY-3-METHOXYBENZONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl bromide (74-96-4) + 3-methoxy-4-hydroxybenzonitrile (4421-08-3) → 4-ethoxy-3-methoxybenzonitrile (81259-56-5)

Guidance literature:

3-methoxy-4-hydroxybenzonitrile; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.583333h;

ethyl bromide; In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1039/c4md00317a

Reference yield: 98.0%

3-methoxy-4-hydroxybenzonitrile (4421-08-3) + ethyl iodide (75-03-6) → 4-ethoxy-3-methoxybenzonitrile (81259-56-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 0 - 40 ℃; for 16h;

Reference yield: 93.0%

4-ethoxy-3-methoxybenzaldehyde oxime (81259-53-2) → 4-ethoxy-3-methoxybenzonitrile (81259-56-5)

Guidance literature:

With phthalic anhydride; for 0.0833333h; Heating;

DOI:10.1002/jccs.200400093

upstream raw materials:

4-ethoxy-3-methoxy-benzaldehyde seqcis-oxime

acetic anhydride

3-methoxy-4-hydroxybenzonitrile

ethyl iodide

Downstream raw materials:

4-ethoxy-3-methoxybenzoic acid

4-ethoxy-3-methoxy-benzoic acid amide

4-ethoxy-5-methoxy-2-nitrobenzonitrile

4-ethoxy-3-methoxy-benzylamine