N-{2-[(1H-Imidazol-2-yl)sulfanyl]phenyl}-4-methylpiperazine-1-carboxamide

Base Information

Chemical Name:N-{2-[(1H-Imidazol-2-yl)sulfanyl]phenyl}-4-methylpiperazine-1-carboxamide
CAS No.:81382-55-0
Molecular Formula:C₁₅H₁₉N₅OS
Molecular Weight:317.415
Hs Code.:
DSSTox Substance ID:DTXSID00524958
Wikidata:Q82392209

Synonyms:81382-55-0;SCHEMBL10984184;DTXSID00524958;N-{2-[(1H-Imidazol-2-yl)sulfanyl]phenyl}-4-methylpiperazine-1-carboxamide

Suppliers and Price of N-{2-[(1H-Imidazol-2-yl)sulfanyl]phenyl}-4-methylpiperazine-1-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of N-{2-[(1H-Imidazol-2-yl)sulfanyl]phenyl}-4-methylpiperazine-1-carboxamide

Chemical Property:

XLogP3:1.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:317.13103142
Heavy Atom Count:22
Complexity:375

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCN(CC1)C(=O)NC2=CC=CC=C2SC3=NC=CN3

Technology Process of N-{2-[(1H-Imidazol-2-yl)sulfanyl]phenyl}-4-methylpiperazine-1-carboxamide

There total 4 articles about N-{2-[(1H-Imidazol-2-yl)sulfanyl]phenyl}-4-methylpiperazine-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 109-01-3
1-methyl-piperazine

: 81382-59-4
imidazo<2,1-b><1,3,5>benzothiadiazepine-5(6H)-one

: 81382-55-0
1-<2-(2-imidazolyl)thiophenyliminocarbonyl>-4-methylpiperazine

Guidance literature:: In dichloromethane; Ambient temperature; overnight;
DOI:10.1002/jhet.5570200528

Reference yield:

: 577-19-5
2-nitrophenyl bromide

: 81382-55-0
1-<2-(2-imidazolyl)thiophenyliminocarbonyl>-4-methylpiperazine

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / NaOC₂H₅ / ethanol / 4 h / Heating

2: 82 percent / iron powder, hydrochloric acid / aq. ethanol / 2 h / Heating

3: triethylamine / CH₂Cl₂ / Ambient temperature; overnight

4: 98 percent / CH₂Cl₂ / Ambient temperature; overnight

With hydrogenchloride; sodium ethanolate; iron; triethylamine; In ethanol; dichloromethane;
DOI:10.1002/jhet.5570200528

Reference yield:

: 81382-50-5
2-[(2-Aminophenyl)thio]-1H-imidazole

: 81382-55-0
1-<2-(2-imidazolyl)thiophenyliminocarbonyl>-4-methylpiperazine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / CH₂Cl₂ / Ambient temperature; overnight

2: 98 percent / CH₂Cl₂ / Ambient temperature; overnight

With triethylamine; In dichloromethane;
DOI:10.1002/jhet.5570200528