81382-50-5Relevant academic research and scientific papers
Phenylthioheterocyclic derivatives
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, (2008/06/13)
Compounds of the formula STR1 wherein n is a integer of 0 to 2; R1 ' and R2 ' are, independently, hydrogen, halogen, trifluoromethyl, lower alkoxy or lower alkyl; and X is pyrimidinyl, thiazolyl or STR2 wherein R is hydrogen, lower alkyl, aryl or ar-lower alkyl; provided that at least one or R1 ' and R2 ' is other than hydrogen, and their pharmaceutically acceptable acid addition salts, and an anti-inflammatory method utilizing a compound of the formula STR3 wherein n is an integer of 0 to 2; R1 and R2 are, independently, hydrogen, halogen, trifluoromethyl, nitro, amino, lower alkylamino, di-lower-alkylamino, lower alkoxy or lower alkyl; and X is pyrimidinyl, thiazolyl or STR4 wherein R is hydrogen, lower alkyl, aryl or ar-lower alkyl; and their pharmaceutically acceptable acid addition salts, are described.
Imidazole systems. I. Imidazo[2,1 b][1,3,5]benzothiadiazepine derivatives as potential antipsychotic agents
Della Vecchia,Dellureficio,Kisis,Vlattas
, p. 1287 - 1294 (2007/10/02)
Imidazo[2,1-b][1,3,5]benzothiadiazepine 3 constitutes a novel ring system, and its analogs 3a-i were synthesized to investigate their potential antipsychotic activity. The synthesis of the ring system was achieved by reaction of 2-aminophenylthioimidazoles 7 with phosgene or thiophosgene and by ring closure of the 1-[2-(2-imidazolyl)thiophenyliminocarbonyl]-1 piperazines 13. An efficient method for the conversion of thioureas 8, 12 to guanidine 3a via the corresponding cyanothioamidines 11, 14 was developed.
5(1-Piperazinyl(imidazo[2,1-b][1,3,5]benzothiadiazepines
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, (2008/06/13)
5-Diazacycloalkyl-imidazo[2,1-b][1,3,5]benzothiadiazepines, e.g. those of the formula STR1 the N-oxides and salts thereof are neuroleptic agents, lacking extrapyramidal side-effects.
