8-Chloro-1-(2-chlorophenyl)-4-(pyrrolidin-1-yl)-3H-2-benzazepine

Base Information

Chemical Name:8-Chloro-1-(2-chlorophenyl)-4-(pyrrolidin-1-yl)-3H-2-benzazepine
CAS No.:81389-23-3
Molecular Formula:C₂₀H₁₈Cl₂N₂
Molecular Weight:357.282
Hs Code.:
DSSTox Substance ID:DTXSID50513675

Synonyms:81389-23-3;DTXSID50513675;8-Chloro-1-(2-chlorophenyl)-4-(pyrrolidin-1-yl)-3H-2-benzazepine;8-Chloro-1-(2-chlorophenyl)-4-(pyrrolidin-1-yl)-3H-benzo[c]azepine

Suppliers and Price of 8-Chloro-1-(2-chlorophenyl)-4-(pyrrolidin-1-yl)-3H-2-benzazepine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 8-Chloro-1-(2-chlorophenyl)-4-(pyrrolidin-1-yl)-3H-2-benzazepine

Chemical Property:

XLogP3:5.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:356.0847040
Heavy Atom Count:24
Complexity:510

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCN(C1)C2=CC3=C(C=C(C=C3)Cl)C(=NC2)C4=CC=CC=C4Cl

Technology Process of 8-Chloro-1-(2-chlorophenyl)-4-(pyrrolidin-1-yl)-3H-2-benzazepine

There total 4 articles about 8-Chloro-1-(2-chlorophenyl)-4-(pyrrolidin-1-yl)-3H-2-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 123-75-1
pyrrolidine

: 76049-64-4
3-amino-1-[2-(2-chlorobenzoyl)-4-chlorophenyl]-propyne

: 81389-23-3
8-chloro-1-(2-chlorophenyl)-4-(1-pyrrolidinyl)-3H-2-benzazepine

Guidance literature:: for 7h; Ambient temperature;
DOI:10.1021/jo00133a040

Reference yield:

: 76049-54-2
N-<<4-chloro-2-(2-chlorobenzoyl)phenyl>-3-propynyl>isoindole-1,3(2H)-dione

: 81389-23-3
8-chloro-1-(2-chlorophenyl)-4-(1-pyrrolidinyl)-3H-2-benzazepine

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / 40percent aq. methylamine / aq. ethanol / 2 h / Ambient temperature

2: 72 percent / 7 h / Ambient temperature

With methylamine; In ethanol;
DOI:10.1021/jo00133a040

Reference yield:

: 76049-50-8
2',5-dichloro-2-iodobenzophenone

: 81389-23-3
8-chloro-1-(2-chlorophenyl)-4-(1-pyrrolidinyl)-3H-2-benzazepine

Guidance literature:: Multi-step reaction with 3 steps

1: 39 percent / triphenylphosphine, palladium chloride, cuprous iodide, diethylamine / CH₂Cl₂ / 20 h / Ambient temperature

2: 97 percent / 40percent aq. methylamine / aq. ethanol / 2 h / Ambient temperature

3: 72 percent / 7 h / Ambient temperature

With copper(l) iodide; diethylamine; triphenylphosphine; methylamine; palladium dichloride; In ethanol; dichloromethane;
DOI:10.1021/jo00133a040