(4-(Hydroxymethyl)phenyl)(phenyl)methanone

Base Information

• Chemical Name: (4-(Hydroxymethyl)phenyl)(phenyl)methanone
• CAS No.: 81449-01-6
• Molecular Formula: C14H12O2
• Molecular Weight: 212.248
• DSSTox Substance ID: DTXSID70522244
• Nikkaji Number: J507.285I
• Wikidata: Q82387350
• Mol file: 81449-01-6.mol

Synonyms:(4-(Hydroxymethyl)phenyl)(phenyl)methanone;81449-01-6;[4-(hydroxymethyl)phenyl]-phenylmethanone;(4-BENZOYLPHENYL)METHANOL;Methanone, [4-(hydroxymethyl)phenyl]phenyl-;[4-(Hydroxymethyl)phenyl](phenyl)methanone;4-Benzoylbenzyl alcohol;4-hydroxymethylbenzophenone;(4-benzoyl-phenyl)-methanol;4-Hydroxylmethyl benzophenone;4-(hydroxymethyl)-benzophenone;SCHEMBL2641948;DTXSID70522244;YZHGHGHCDSLOBP-UHFFFAOYSA-N;(4-methylolphenyl)-phenyl-methanone;MFCD26131247;AKOS024262446;[4-(Hydroxymethyl)phenyl]phenyl-methanone;AS-65343;methanone,(4-(hydroxymethyl)phenyl)phenyl-;CS-0156558;NS00128888;A864549

Chemical Property of (4-(Hydroxymethyl)phenyl)(phenyl)methanone

Chemical Property:

• PSA: 37.30000
• LogP: 2.40990
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 212.083729621
• Heavy Atom Count: 16
• Complexity: 223

Purity/Quality:

99% ^*data from raw suppliers

(4-(Hydroxymethyl)phenyl)(phenyl)methanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)CO

Technology Process of (4-(Hydroxymethyl)phenyl)(phenyl)methanone

There total 20 articles about (4-(Hydroxymethyl)phenyl)(phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-(1-hydroxy-1-phenylmethyl)benzyl alcohol (88682-29-5) → 4-(hydroxymethyl)benzophenone (81449-01-6)

Guidance literature:

With potassium carbonate; dimethyl sulfoxide; at 125 ℃; chemoselective reaction;

DOI:10.1039/c5cc05713b

Reference yield: 92.0%

[4-(2-phenyl-1,3-dioxolan-2-yl)phenyl]methanol → 4-(hydroxymethyl)benzophenone (81449-01-6)

Guidance literature:

With acetic acid; In tetrahydrofuran; water; at 65 ℃; for 16h;

Reference yield: 91.4%

potassium (acetoxymethyl)trifluoroborate + 4-chlorobenzophenone (134-85-0) → 4-(hydroxymethyl)benzophenone (81449-01-6)

Guidance literature:

With sodium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; ruphos; In 1,4-dioxane; water; for 24h; Inert atmosphere; Reflux;

DOI:10.1021/ol300149b

upstream raw materials:

4-(bromomethyl)benzophenone

methanol

benzophenone

4-carboxybenzophenone

Downstream raw materials:

4-[(tributylstannyl)oxymethyl]-benzophenone

4-benzoylbenzaldehyde

4-Hydroxymethyl benzophenone hydrazone

4-(allyloxymethyl)benzophenone

Refernces

• 1、 Ali, Lamiaa M. A.,Baccon-Sollier, Paul Le,Cuq, Pierre,Lichon, Laure,Malki, Yohan,Masurier, Nicolas,Maye, Morgane,Vincent, Laure-Ana?s. "Imidazopyridine-fused [1,3]diazepinones: modulations of positions 2 to 4 and their impacts on the anti-melanoma activity". . p. 935 - 949. Retrieved 2020/04/17.
• 2、 Jin, Fengli,Han, Wei. "Transition-metal-free, ambient-pressure carbonylative cross-coupling reactions of aryl halides with potassium aryltrifluoroborates". supporting information. p. 9133 - 9136. Retrieved 2015/06/08.