2-(3,5-Dibromophenyl)-2-methyl-1,3-dioxolane

Base Information

• Chemical Name: 2-(3,5-Dibromophenyl)-2-methyl-1,3-dioxolane
• CAS No.: 81500-93-8
• Molecular Formula: C10H10Br2O2
• Molecular Weight: 321.996
• DSSTox Substance ID: DTXSID401255757
• Mol file: 81500-93-8.mol

Synonyms:2-(3,5-dibromophenyl)-2-methyl-1,3-dioxolane;81500-93-8;SCHEMBL8344971;DTAWQXMXTCLJBL-UHFFFAOYSA-N;DTXSID401255757

Chemical Property of 2-(3,5-Dibromophenyl)-2-methyl-1,3-dioxolane

Chemical Property:

• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 321.90271
• Heavy Atom Count: 14
• Complexity: 194

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1(OCCO1)C2=CC(=CC(=C2)Br)Br

Technology Process of 2-(3,5-Dibromophenyl)-2-methyl-1,3-dioxolane

There total 1 articles about 2-(3,5-Dibromophenyl)-2-methyl-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3,5-dibromoacetophenone (14401-73-1) + ethylene glycol (107-21-1) → 2-(3,5-dibromophenyl)-2-methyl-(1,3)-dioxolane (81500-93-8)

Guidance literature:

With toluene-4-sulfonic acid; for 6h; Heating;

DOI:10.1016/S0022-328X(00)86823-0

Reference yield: 65.0%

chloro-trimethyl-silane (75-77-4) + 2-(3,5-dibromophenyl)-2-methyl-(1,3)-dioxolane (81500-93-8) → 2-<3,5-bis(trimethylsilyl)phenyl>-2-methyl-(1,3)-dioxolane (81500-95-0)

Guidance literature:

With magnesium; In tetrahydrofuran; at 20 ℃; for 14h;

DOI:10.1016/S0022-328X(00)86823-0

Reference yield:

2-(3,5-dibromophenyl)-2-methyl-(1,3)-dioxolane (81500-93-8) → 3,5-bis(trimethylsilyl)acetophenone (81500-98-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / Mg / tetrahydrofuran / 14 h / 20 °C

2: 10percent HCl / tetrahydrofuran / 2 h / 20 °C

With hydrogenchloride; magnesium; In tetrahydrofuran;

DOI:10.1016/S0022-328X(00)86823-0

upstream raw materials:

3,5-dibromoacetophenone

ethylene glycol

Downstream raw materials:

2-<3,5-bis(trimethylsilyl)phenyl>-2-methyl-(1,3)-dioxolane

3,5-bis(trimethylsilyl)acetophenone