Oxiranecarbonitrile, 3-(4-methoxyphenyl)-

Base Information

• Chemical Name: Oxiranecarbonitrile, 3-(4-methoxyphenyl)-
• CAS No.: 81860-68-6
• Molecular Formula: C10H9NO2
• Molecular Weight: 175.187
• Mol file: 81860-68-6.mol

Synonyms:

Chemical Property of Oxiranecarbonitrile, 3-(4-methoxyphenyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Oxiranecarbonitrile, 3-(4-methoxyphenyl)-

There total 7 articles about Oxiranecarbonitrile, 3-(4-methoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-methoxy-benzaldehyde (123-11-5) + chloroacetonitrile (107-14-2) → 3-(4-methoxyphenyl)-oxiranecarbonitrile (81860-68-6)

Guidance literature:

With sodium hydroxide; N-benzyl-trimethylammonium hydroxide; In methanol; toluene; at 15 - 20 ℃; for 0.5h;

DOI:10.1002/ardp.19823150314

Reference yield: 15.0%

4-methoxy-benzaldehyde (123-11-5) + chloroacetonitrile (107-14-2) → cis-3-(4-methoxyphenyl)oxirane-2-carbonitrile (33984-91-7,33984-92-8,81860-68-6)

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; at 20 ℃; for 10h; Green chemistry;

DOI:10.1039/c9ob02428j

Reference yield:

(E)-p-methoxycinnamonitrile (14482-11-2) → (E)-3-(4-methoxyphenyl)-oxirane-carbonitrile (33984-91-7,33984-92-8,81860-68-6)

Guidance literature:

With 3,3-dimethyldioxirane; In acetone; at 25 ℃;

DOI:10.1021/ja075068u

upstream raw materials:

chloroacetonitrile

4-methoxy-benzaldehyde

chloroacetonitrile

(E)-p-methoxycinnamonitrile

Downstream raw materials:

4-Methoxyphenylacetic acid

8-hydroxy-5-<2-<<2-(4-hydroxyphenyl)ethyl>-n-propylamino>ethyl>carbostyril

8-hydroxy-5-<2-<<2-(4-hydroxyphenyl)ethyl>amino>ethyl>carbostyril hydrobromide

5-<2-<<2-(4-methoxyphenyl)-2-hydroxyethyl>amino>ethyl>-8-methoxycarbostyril

Refernces

• 1、 Annese, Cosimo,D'Accolti, Lucia,Dinoi, Anna,Fusco, Caterina,Gandolfi, Remo,Curci, Ruggero. "Concerning the reactivity of dioxiranes. Observations from experiments and theory". . p. 1197 - 1204. Retrieved 2008/09/20.
• 2、 Kaiser, Carl,Dandrige, Penelope A.,Garvey, Eleanor,Flaim, Kathryn E.,Zeid, Robert L.,Hieble, J. Paul. "Dopamine Receptor Agonist Activity of Some 5-(2-Aminoethyl)carbostyril Derivatives". . p. 1803 - 1810. Retrieved 2007/10/02.