N-[(Benzyloxy)carbonyl]-L-phenylalanyl-L-alanyl-L-serine

Base Information

Chemical Name:N-[(Benzyloxy)carbonyl]-L-phenylalanyl-L-alanyl-L-serine
CAS No.:820239-50-7
Molecular Formula:C23H27N3O7
Molecular Weight:457.483
Hs Code.:
DSSTox Substance ID:DTXSID80514478
Wikidata:Q82374832

Synonyms:820239-50-7;DTXSID80514478;N-[(Benzyloxy)carbonyl]-L-phenylalanyl-L-alanyl-L-serine

Suppliers and Price of N-[(Benzyloxy)carbonyl]-L-phenylalanyl-L-alanyl-L-serine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 0 raw suppliers

Chemical Property of N-[(Benzyloxy)carbonyl]-L-phenylalanyl-L-alanyl-L-serine

Chemical Property:

XLogP3:1.5
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:12
Exact Mass:457.18490021
Heavy Atom Count:33
Complexity:660

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C(=O)NC(CO)C(=O)O)NC(=O)C(CC1=CC=CC=C1)NC(=O)OCC2=CC=CC=C2
Isomeric SMILES:C[C@@H](C(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)OCC2=CC=CC=C2

Technology Process of N-[(Benzyloxy)carbonyl]-L-phenylalanyl-L-alanyl-L-serine

There total 4 articles about N-[(Benzyloxy)carbonyl]-L-phenylalanyl-L-alanyl-L-serine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 56-45-1,83245-15-2
L-serin

: 769922-78-3
benzyl N-((1S)-2-{[(1S)-2-(1H-1,2,3-benzotriazol-1-yl)-1-methyl-2-oxoethyl]amino}-1-benzyl-2-oxoethyl)carbamate

: 820239-50-7
(5S,8S,11S)-5-benzyl-11-(hydroxymethyl)-8-methyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazadodecan-12-oic acid

Guidance literature:: With triethylamine; In water; acetonitrile; at 20 ℃;
DOI:10.1055/s-2004-831255

Reference yield:

: 3338-39-4,16088-00-9,16088-38-3,17563-25-6,55387-02-5,80996-16-3,21881-18-5
N-benzyloxycarbonyl-L-phenylalanyl-L-alanine

: 820239-50-7
(5S,8S,11S)-5-benzyl-11-(hydroxymethyl)-8-methyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazadodecan-12-oic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: SOCl₂ / tetrahydrofuran / 0.33 h / 25 °C

1.2: 85 percent / tetrahydrofuran / 2 h / 0 °C

2.1: 94 percent / Et₃N / acetonitrile; H₂O / 20 °C

With thionyl chloride; triethylamine; In tetrahydrofuran; water; acetonitrile;
DOI:10.1055/s-2004-831255

Reference yield:

: 1161-13-3
N-Cbz-L-Phe

: 820239-50-7
(5S,8S,11S)-5-benzyl-11-(hydroxymethyl)-8-methyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazadodecan-12-oic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: SOCl₂ / tetrahydrofuran / 0.33 h / 25 °C

1.2: 89 percent / tetrahydrofuran / 1 h / 25 °C

2.1: 96 percent / Et₃N / acetonitrile; H₂O / 20 °C

3.1: SOCl₂ / tetrahydrofuran / 0.33 h / 25 °C

3.2: 85 percent / tetrahydrofuran / 2 h / 0 °C

4.1: 94 percent / Et₃N / acetonitrile; H₂O / 20 °C

With thionyl chloride; triethylamine; In tetrahydrofuran; water; acetonitrile;
DOI:10.1055/s-2004-831255