769922-78-3

Upstream product

• 95-14-7 1,2,3-Benzotriazole 
• 3338-39-4 N-benzyloxycarbonyl-L-phenylalanyl-L-alanine 
• 769922-77-2 (S)-benzyl (1-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxo-3-phenylpropan-2-yl)carbamate 
• 1161-13-3 N-Cbz-L-Phe 

Downstream Products

• 19245-90-0 (5S,8S,11S)-5-benzyl-8,11-dimethyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazadodecan-12-oic acid 
• 820239-50-7 (5S,8S,11S)-5-benzyl-11-(hydroxymethyl)-8-methyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazadodecan-12-oic acid 
• 1463037-07-1 benzyl ((S)-1-(((S)-1-(benzo[d]thiazol-2-yl)ethyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate 
• 1039552-97-0 benzyl {(S)-1-[(S)-1-(6-methoxybenzothiazol-2-ylcarbamoyl)ethylcarbamoyl]-2-phenylethyl}carbamate 
• 1621538-69-9 S-{[(benzyloxy)carbonyl]-L-alanyl}-N-[(benzyloxy)carbonyl]-L-phenylalanyl-L-alanyl-L-cysteine 
• 1621538-61-1 [(benzyloxy)carbonyl]-L-phenylalanyl-L-alanyl-L-cysteine 

Relevant academic research and scientific papers

Highly diastereoselective peptide chain extensions of unprotected amino acids with N-(Z-α-aminoacyl)benzotriazoles

Coupling an unprotected amino acid or dipeptide in partially aqueous solution with a readily available N-(Z-α-amino-acyl)benzotriazole or N-(Z-α-aminopetidoyl)benzotriazole affords N-terminal-protected di-, tri-, and tetrapeptides in yields of 85-98% (average 95% for 2a-i, 93% for 4a-f and 4a′, 86% for 5a-b) with minimal epimerization.