5-(2-Fluoro-6-methoxyphenyl)oxazolidine-2,4-dione

Base Information

Chemical Name:5-(2-Fluoro-6-methoxyphenyl)oxazolidine-2,4-dione
CAS No.:82128-26-5
Molecular Formula:C10H8FNO4
Molecular Weight:225.176
Hs Code.:
ChEMBL ID:CHEMBL351381
DSSTox Substance ID:DTXSID70517913

Synonyms:5-(2-Fluoro-6-methoxyphenyl)oxazolidine-2,4-dione;82128-26-5;5-(2-Fluoro-6-methoxyphenyl)-1,3-oxazolidine-2,4-dione;CHEMBL351381;SCHEMBL10893526;DTXSID70517913;UFKAYRNOYLAMAV-UHFFFAOYSA-N

Suppliers and Price of 5-(2-Fluoro-6-methoxyphenyl)oxazolidine-2,4-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 5-(2-Fluoro-6-methoxyphenyl)oxazolidine-2,4-dione

Chemical Property:

XLogP3:1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:225.04373590
Heavy Atom Count:16
Complexity:309

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C(=CC=C1)F)C2C(=O)NC(=O)O2

Technology Process of 5-(2-Fluoro-6-methoxyphenyl)oxazolidine-2,4-dione

There total 5 articles about 5-(2-Fluoro-6-methoxyphenyl)oxazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 82128-13-0
5-(2,6-difluorophenyl)oxazolidine-2,4-dione

: 82128-26-5
5-(2-fluoro-6-methoxyphenyl)oxazolidine-2,4-dione

Guidance literature:: With hydrogenchloride; potassium tert-butylate; In methanol; sodium hydroxide; dimethyl sulfoxide;

Reference yield: 62.0%

: 67-56-1
methanol

: 82128-13-0
5-(2,6-difluorophenyl)oxazolidine-2,4-dione

: 82128-26-5
5-(2-fluoro-6-methoxyphenyl)oxazolidine-2,4-dione

Guidance literature:: With potassium tert-butylate; In dimethyl sulfoxide; at 155 ℃; for 4h;
DOI:10.1021/jm00155a030

Reference yield:

: 437-81-0
2,6-difluorobenzaldehyde

: 82128-26-5
5-(2-fluoro-6-methoxyphenyl)oxazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1: ZnI₂ / CH₂Cl₂ / 65 h / Ambient temperature

2: 88 percent / HCl / 16 h / 5 °C

3: 57 percent / Et₃N / tetrahydrofuran / 1 h / 0 - 5 °C

4: 62 percent / potassium tert-butoxide / dimethylsulfoxide / 4 h / 155 °C

With hydrogenchloride; potassium tert-butylate; triethylamine; zinc(II) iodide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm00155a030