Elafibranor

Base Information

Chemical Name:Elafibranor
CAS No.:824932-88-9
Molecular Formula:C₂₂H₂₄O₄S
Molecular Weight:384.496
Hs Code.:
European Community (EC) Number:815-538-9
UNII:2J3H5C81A5
DSSTox Substance ID:DTXSID601045330
Wikipedia:Elafibranor
Wikidata:Q15409440
NCI Thesaurus Code:C166574
Pharos Ligand ID:LD5N9FSHLGTT
Metabolomics Workbench ID:149413
ChEMBL ID:CHEMBL3707395

Synonyms:2-(2,6-dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxo-1-propenyl)phenoxyl)-2-methylpropanoic acid;elafibranor;GFT505

Suppliers and Price of Elafibranor

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 14 raw suppliers

Chemical Property of Elafibranor

Chemical Property:

Melting Point:140-144°C
Boiling Point:569.0±50.0 °C(Predicted)
PKA:3.34±0.11(Predicted)
PSA：88.90000
Density:1.21±0.1 g/cm3(Predicted)
LogP:5.16340
Storage Temp.:Amber Vial, -20°C Freezer
Solubility.:DMSO (Slightly), Methanol (Slightly)
XLogP3:5.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:384.13953042
Heavy Atom Count:27
Complexity:537

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=CC(=C1OC(C)(C)C(=O)O)C)C=CC(=O)C2=CC=C(C=C2)SC
Isomeric SMILES:CC1=CC(=CC(=C1OC(C)(C)C(=O)O)C)/C=C/C(=O)C2=CC=C(C=C2)SC
Recent ClinicalTrials:A Study to Evaluate the Effect of Food on the Level of Circulating Elafibranor in Healthy Participants After Intake of a Single Tablet
Recent EU Clinical Trials:A Phase II, Multicenter, Double-Blind, Randomised, Placebo-Controlled Study and Open-Label Long Term Extension to Evaluate the Safety and Efficacy of Elafibranor in Adult Participants with Primary Sclerosing Cholangitis (PSC)
Uses GFT-505 is a?dual?PPARα/δ agonist. Studies have shown that GFT-505 improves hepatic and peripheral insulin sensitivity in abdominally obese subjects. It may also be a potential new drug candidate for treating lipid and glucose disorders.

Technology Process of Elafibranor

There total 26 articles about Elafibranor which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: allyl (E)-2-(2,6-dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxoprop-1-en-1-yl)phenoxy)-2-methylpropanoate

: 824932-88-9,923978-27-2
2-(2,6-dimethyl-4-{(1E)-3-[4-(methylsulfanyl)phenyl]-3-oxoprop-1-en-1-yl}phenoxy)-2-methylpropanoic acid

Guidance literature:: With water; sodium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 22h;

Reference yield: 82.5%

: (2E)-3-(4-hydroxy-3,5-dimethylphenyl)-1-[4-(methylsulfanyl)phenyl]prop-2-en-1-one

: 2052-01-9
2-bromo-2-methylpropionic acid

: 824932-88-9,923978-27-2
2-(2,6-dimethyl-4-{(1E)-3-[4-(methylsulfanyl)phenyl]-3-oxoprop-1-en-1-yl}phenoxy)-2-methylpropanoic acid

Guidance literature:: (2E)-3-(4-hydroxy-3,5-dimethylphenyl)-1-[4-(methylsulfanyl)phenyl]prop-2-en-1-one; With sodium hydroxide; In acetonitrile; at 70 ℃; for 1h;

2-bromo-2-methylpropionic acid; In acetonitrile; for 2h; Temperature; Solvent; Reagent/catalyst;