2-Propen-1-one, 3-(4-hydroxy-3,5-dimethylphenyl)-1-[4-(methylthio)phenyl]-

Base Information

Chemical Name:2-Propen-1-one, 3-(4-hydroxy-3,5-dimethylphenyl)-1-[4-(methylthio)phenyl]-
CAS No.:824932-89-0
Molecular Formula:C18H18O2S
Molecular Weight:298.406
Hs Code.:

Synonyms:2-Propen-1-one, 3-(4-hydroxy-3,5-dimethylphenyl)-1-[4-(methylthio)phenyl]-;1-[4-methylthiophenyl]-3-[3,5-dimethyl-4-hydroxyphenyl]prop-2-en-1-one;

Suppliers and Price of 2-Propen-1-one, 3-(4-hydroxy-3,5-dimethylphenyl)-1-[4-(methylthio)phenyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-(4-Methylthiophenyl)-3-(3,5-dimethyl-4-hydroxyphenyl)prop-2-en-1-one
100mg
$ 55.00

TRC
1-(4-Methylthiophenyl)-3-(3,5-dimethyl-4-hydroxyphenyl)prop-2-en-1-one
2.5g
$ 930.00

ChemScene
2-Propen-1-one,3-(4-hydroxy-3,5-dimethylphenyl)-1-[4-(methylthio)phenyl]-
100mg
$ 850.00

Total 9 raw suppliers

Chemical Property of 2-Propen-1-one, 3-(4-hydroxy-3,5-dimethylphenyl)-1-[4-(methylthio)phenyl]-

Chemical Property:

PSA：62.60000
LogP:4.62700

Purity/Quality:

98%+ ^*data from raw suppliers

1-(4-Methylthiophenyl)-3-(3,5-dimethyl-4-hydroxyphenyl)prop-2-en-1-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 1-(4-Methylthiophenyl)-3-(3,5-dimethyl-4-hydroxyphenyl)prop-2-en-1-one is an intermediate in synthesizing GFT-505 (G368870), which is a?dual?PPARα/δ agonist. Studies have shown that GFT-505 improves hepatic and peripheral insulin sensitivity in abdominally obese subjects. It may also be a potential new drug candidate for treating lipid and glucose disorders.

Technology Process of 2-Propen-1-one, 3-(4-hydroxy-3,5-dimethylphenyl)-1-[4-(methylthio)phenyl]-

There total 1 articles about 2-Propen-1-one, 3-(4-hydroxy-3,5-dimethylphenyl)-1-[4-(methylthio)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1778-09-2
4-(Methylthio)acetophenone

: 2233-18-3
4-hydroxy-3,5-dimethylbenzaldehyde

: 824932-89-0
1-[4-methylthiophenyl]-3-[3,5-dimethyl-4-hydroxyphenyl]prop-2-en-1-one

Guidance literature:: With hydrogenchloride; In methanol; water; at 0 - 40 ℃; for 16h; Temperature; Concentration; Large scale;

Reference yield: 75.0%

: 1350817-83-2
tert-butyl 2-methyl-2-(methylsulfonyloxy)propanoate

: 824932-89-0
1-[4-methylthiophenyl]-3-[3,5-dimethyl-4-hydroxyphenyl]prop-2-en-1-one

: 824932-90-3
1-[4-methylthiophenyl]-3-[3,5-dimethyl-4-(tertbutyloxycarbonyldimethylmethyloxy)phenyl]prop-2-en-1-one

Guidance literature:: With tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; In water; toluene; for 66h; Product distribution / selectivity; Reflux; Inert atmosphere;