Acetamide, N-[(1R,2R)-2-(1-piperidinyl)cyclohexyl]-

Base Information

Chemical Name:Acetamide, N-[(1R,2R)-2-(1-piperidinyl)cyclohexyl]-
CAS No.:824938-91-2
Molecular Formula:C13H24N2O
Molecular Weight:224.346
Hs Code.:
DSSTox Substance ID:DTXSID50478750
Wikidata:Q82312325

Synonyms:824938-91-2;Acetamide, N-[(1R,2R)-2-(1-piperidinyl)cyclohexyl]-;DTXSID50478750

Suppliers and Price of Acetamide, N-[(1R,2R)-2-(1-piperidinyl)cyclohexyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 0 raw suppliers

Chemical Property of Acetamide, N-[(1R,2R)-2-(1-piperidinyl)cyclohexyl]-

Chemical Property:

XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:224.188863393
Heavy Atom Count:16
Complexity:236

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)NC1CCCCC1N2CCCCC2
Isomeric SMILES:CC(=O)N[C@@H]1CCCC[C@H]1N2CCCCC2

Technology Process of Acetamide, N-[(1R,2R)-2-(1-piperidinyl)cyclohexyl]-

There total 7 articles about Acetamide, N-[(1R,2R)-2-(1-piperidinyl)cyclohexyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 111-24-0
1,5-dibromo-pentane

: 320778-89-0
N-((1R,2R)-2-aminocyclohexyl)acetamide

: 824938-91-2
N-[((1R,2R)-2-piperidin-1-yl)-cyclohexyl]acetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 90 ℃; for 3h; Microwave irradiation;
DOI:10.1039/c3ob41709c

Reference yield: 45.0%

: 18468-90-1,824938-80-9,824938-98-9
(+/-)-trans-2-(piperidin-1-yl)cyclohexanamine

: 141-78-6
ethyl acetate

: 501-53-1,94274-21-2
benzyl chloroformate

: 824938-91-2
N-[((1R,2R)-2-piperidin-1-yl)-cyclohexyl]acetamide

: 824938-85-4
benzyl (1S,2S)-N-[2-(piperidin-1-yl)cyclohexyl]carbamate

Guidance literature:: (+/-)-trans-2-(piperidin-1-yl)cyclohexanamine; ethyl acetate; With Candida antarctica lipase B; at 28 ℃; for 8h;

benzyl chloroformate; at 0 ℃; for 15h;
DOI:10.1002/chem.200400607

Reference yield:

: 110-89-4
piperidine

: 824938-91-2
N-[((1R,2R)-2-piperidin-1-yl)-cyclohexyl]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / 18 h / Heating

2.1: MsCl; Et₃N / diethyl ether / 0 - 20 °C

2.2: aq. NH₃ / diethyl ether / 16 h / 20 °C

3.1: Candida antarctica lipase B / 8 h / 28 °C

With Candida antarctica lipase B; methanesulfonyl chloride; triethylamine; In diethyl ether; ethanol;
DOI:10.1002/chem.200400607