1-Hexanol, 6-(dimethylamino)-

Base Information

• Chemical Name: 1-Hexanol, 6-(dimethylamino)-
• CAS No.: 1862-07-3
• Molecular Formula: C8H19 N O
• Molecular Weight: 145.245
• Hs Code.: 2922199090
• European Community (EC) Number: 404-680-3,638-811-2
• NSC Number: 165607
• DSSTox Substance ID: DTXSID3062023
• Nikkaji Number: J124.892H
• Wikidata: Q81989801
• Mol file: 1862-07-3.mol

Synonyms:1862-07-3;6-(dimethylamino)hexan-1-ol;6-Dimethylamino-1-hexanol;1-HEXANOL, 6-(DIMETHYLAMINO)-;6-(dimethylamino)-1-hexanol;6-dimethylaminohexanol;6-dimethylaminohexan-1-ol;EC 404-680-3;6-Dimethyl amino hexanol-1;NSC165607;6-(Dimethylamino)hexanol;C(CCCCO)CN(C)C;N,N-dimethyl 6-aminohexanol;SCHEMBL140287;DTXSID3062023;N,N-dimethyl-6-amino-1-hexanol;>97%;MFCD00046028;AKOS024462432;NSC 165607;NSC-165607;SB83842;D1664;FT-0621103;D89905

Chemical Property of 1-Hexanol, 6-(dimethylamino)-

Chemical Property:

• Vapor Pressure: 0.0656mmHg at 25°C
• Refractive Index: 1.4460-1.4500
• Boiling Point: 203.8°Cat760mmHg
• PKA: 15.19±0.10(Predicted)
• Flash Point: 63.6°C
• PSA: 23.47000
• Density: 0.878g/cm³
• LogP: 1.10070
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Sparingly), Methanol (Slightly)
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 6
• Exact Mass: 145.146664230
• Heavy Atom Count: 10
• Complexity: 64.3

Purity/Quality:

99.9% ^*data from raw suppliers

6-(Dimethylamino)-1-hexanol ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C
• Statements: 10-20/21/22-34-52/53-22
• Safety Statements: 16-26-36/37/39-45-61

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)CCCCCCO
• Uses: An alkanolamine as lysosomotropic agent and choline uptake inhibitor.

Technology Process of 1-Hexanol, 6-(dimethylamino)-

There total 23 articles about 1-Hexanol, 6-(dimethylamino)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

→ 6-(N,N-dimethylamino)-1-hexanol (1862-07-3)

Guidance literature:

With 5percent silver supported on titanium oxide; at 25 ℃; for 10h; Inert atmosphere; Sealed tube; UV-irradiation;

Reference yield: 97.0%

methanol (67-56-1) + 6-amino-1-hexanol (4048-33-3) → 6-(N,N-dimethylamino)-1-hexanol (1862-07-3)

Guidance literature:

With bis[dichloro(pentamethylcyclopentadienyl)ruthenium(III)]; bis[2-(diphenylphosphino)phenyl] ether; lithium tert-butoxide; at 100 ℃; for 24h;

DOI:10.1021/acscatal.5b00606

Reference yield:

N-(6-hydroxy-hexyl)-N,N-dimethyl-hydrazinium; chloride → 6-(N,N-dimethylamino)-1-hexanol (1862-07-3)

Guidance literature:

With hydrogenchloride; sodium hydroxide; sodium nitrite; Multistep reaction; 1.) 0 deg C;

DOI:10.1016/S0040-4039(98)02350-8

upstream raw materials:

N,N-dimethyl-adipamic acid ethyl ester

6-chloro-1-hexanol

dimethyl amine

N-Methyl-6-hydroxyhexylamine

Downstream raw materials:

bis[6-(N,N-dimethylamino)hexyl] disulfide

6-(N,N-dimethylamino)hexyl octyl fumarate

2-[6-(N,N-dimethylamino)hexylthio]-3-dimethyloctylsilyl-1,3-butadiene

[6-(4-dimethylamino-butylsulfanyl)-hexyl]-dimethyl-amine

Refernces

• 1、 Ringsdorf,Thunig. "". . p. 2205. Retrieved 1977.
• 2、 -. "Method for homogeneously catalyzing alcohol amination". Paragraph 0069; 0075-0079. . Retrieved 2019/02/21.
• 3、 Dang, Tuan Thanh,Ramalingam, Balamurugan,Seayad, Abdul Majeed. "Efficient ruthenium-catalyzed N-methylation of amines using methanol". . p. 4082 - 4088. Retrieved 2015/11/11.