1,4-Dioxane, 2-phenyl-

Base Information

• Chemical Name: 1,4-Dioxane, 2-phenyl-
• CAS No.: 827-53-2
• Molecular Formula: C10H12O2
• Molecular Weight: 164.204
• Mol file: 827-53-2.mol

Synonyms:

Chemical Property of 1,4-Dioxane, 2-phenyl-

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4-Dioxane, 2-phenyl-

There total 10 articles about 1,4-Dioxane, 2-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

1,4-dioxane (123-91-1,28347-88-8,28347-91-3,39449-24-6,54841-74-6) + phenylboronic acid (98-80-6) → 2-phenyl-1,4-dioxane (827-53-2)

Guidance literature:

1,4-dioxane; phenylboronic acid; With bis(acetylacetonate)nickel(II); potassium phosphate; triphenylphosphine; for 0.0833333h; Inert atmosphere; Schlenk technique;

With di-tert-butyl peroxide; at 100 ℃; for 16h; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.201300459

Reference yield: 61.0%

1,4-dioxane (123-91-1,28347-88-8,28347-91-3,39449-24-6,54841-74-6) + phenylmagnesium chloride (100-59-4) → 2-phenyl-1,4-dioxane (827-53-2)

Guidance literature:

With C₃₁H₃₈ClN₃NiO₂^(1-)*Li⁽¹⁺⁾; In diethyl ether; ethylene dibromide; at 25 ℃; for 1h; Inert atmosphere;

DOI:10.1007/s10562-013-1170-8

Reference yield:

phenylmagnesium bromide → 2-phenyl-1,4-dioxane (827-53-2)

Guidance literature:

With diethyl ether;

DOI:10.1021/ja01315a009

upstream raw materials:

styrene oxide

ethylene glycol

tetrahydrofuran

phenyldiazomethane

Refernces

• 1、 Gartia, Yashraj,Ramidi, Punnamchandar,Cheerla, Sreevishnu,Felton, Charlette M.,Jones, Darin E.,Das, Bhaskar C.,Ghosh, Anindya. "Activation of sp3 and sp2 C-H bonds of oxygen containing heterocyclic molecules for alkylation and arylation reactions catalyzed by an iron complex". . p. 253 - 259. Retrieved 2014/07/07.
• 2、 -. "New-quanidino-thiazol compounds, their preparation, and use as intermediates of famotidine process". . . Retrieved 2008/06/13.