2-METHOXYCHALCONE

Base Information

• Chemical Name: 2-METHOXYCHALCONE
• CAS No.: 5416-70-6
• Molecular Formula: C16H14 O2
• Molecular Weight: 238.286
• Hs Code.: 2914509090
• Mol file: 5416-70-6.mol

Synonyms:Chalcone, 2-methoxy- (6CI,7CI,8CI); 2-Methoxychalcone; NSC11865; NSC 636918; o-Methoxychalcone

Chemical Property of 2-METHOXYCHALCONE

Chemical Property:

• Vapor Pressure: 4.26E-06mmHg at 25°C
• Boiling Point: 383.9°Cat760mmHg
• Flash Point: 171.6°C
• PSA: 26.30000
• Density: 1.114g/cm³
• LogP: 3.59130

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-METHOXYCHALCONE

There total 12 articles about 2-METHOXYCHALCONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.1%

acetophenone (98-86-2) + ortho-anisaldehyde (135-02-4) → 2-methoxychalcone (5416-70-6)

Guidance literature:

With potassium hydroxide; In ethanol; at 20 ℃; for 4h;

DOI:10.1021/jm901004c

Reference yield: 92.0%

(2-methoxyphenyl)methanol (612-16-8) + acetophenone (98-86-2) → 2-methoxychalcone (5416-70-6)

Guidance literature:

With oxygen; caesium carbonate; In acetonitrile; at 20 ℃; for 24h; chemoselective reaction;

DOI:10.1016/j.mcat.2021.111516

Reference yield: 90.0%

2-Methoxyacetophenone (579-74-8) + benzaldehyde (100-52-7) → 2-methoxychalcone (5416-70-6)

Guidance literature:

With sulfuric acid; In 1,4-dioxane; at 90 ℃; for 2h; Inert atmosphere;

upstream raw materials:

acetophenone

ortho-anisaldehyde

dimethyl sulfate

3-methoxy-benzaldehyde

Downstream raw materials:

6-(2-methoxy-phenyl)-2-oxo-4-phenyl-cyclohex-3-enecarboxylic acid ethyl ester

(2S,3R)-2-Benzoyl-3-(2-methoxy-phenyl)-cyclopropane-1,1-dicarbonitrile

2-Bromo-4-(2-methoxy-phenyl)-6-phenyl-nicotinonitrile

2-Bromo-2-[1-(2-methoxy-phenyl)-3-oxo-3-phenyl-propyl]-malononitrile

Refernces

• 1、 Farahi, Mahnaz,Karami, Bahador,Keshavarz, Raziyeh,Nia, Forough Motamedi. "Synthesis of chalcone derivatives by phthalhydrazide-functionalized tio2-coated nano-fe3o4 as a new heterogeneous catalyst". . p. 407 - 414. Retrieved 2021/09/07.
• 2、 Yue, Guizhou,Jiang, Dan,Dou, Zhengjie,Li, Sicheng,Feng, Juhua,Zhang, Li,Chen, Huabao,Yang, Chunping,Yin, Zhongqiong,Song, Xu,Liang, Xiaoxia,Wang, Xianxiang,Lu, Cuifen. "Rapid umpolung Michael addition of isatin N, N ′-cyclic azomethine imine 1,3-dipoles with chalcones". supporting information. p. 11712 - 11718. Retrieved 2021/07/12.