Mirabegron Impurity

Base Information

• Chemical Name: Mirabegron Impurity
• CAS No.: 83303-98-4
• Molecular Formula: C16H16N2O3
• Molecular Weight: 284.31000
• Mol file: 83303-98-4.mol

Synonyms:N-[2-(4-Nitro-phenyl)-ethyl]-2-phenyl-acetamide;

Chemical Property of Mirabegron Impurity

Chemical Property:

• PSA: 74.92000
• LogP: 3.41030

Purity/Quality:

>95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Mirabegron Impurity

There total 3 articles about Mirabegron Impurity which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

p-nitrobenzylamine (7409-30-5) + phenylacetyl chloride (103-80-0) → 4-(2-(((phenylmethyl)carbonyl)amino)ethyl)nitrobenzene (83303-98-4)

Guidance literature:

With triethylamine; In chloroform; at 0 ℃;

DOI:10.1002/hlca.19820650314

Reference yield:

phenylacetic acid (103-82-2) + 2-(4-nitrophenyl)ethylamine monohydrochloride (29968-78-3) → 4-(2-(((phenylmethyl)carbonyl)amino)ethyl)nitrobenzene (83303-98-4)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide;

DOI:10.1016/j.cclet.2017.11.041

Reference yield:

→ 4-(2-(((phenylmethyl)carbonyl)amino)ethyl)nitrobenzene (83303-98-4)

Guidance literature:

upstream raw materials:

p-nitrobenzylamine

phenylacetyl chloride

phenylacetic acid

2-(4-nitrophenyl)ethylamine monohydrochloride

Refernces

• 1、 -. "AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES". . . Retrieved 2008/06/13.