Methanone, [3-iodo-4-(1-pyrrolidinyl)phenyl]phenyl-

Base Information

Chemical Name:Methanone, [3-iodo-4-(1-pyrrolidinyl)phenyl]phenyl-
CAS No.:834895-51-1
Molecular Formula:C₁₇H₁₆INO
Molecular Weight:377.225
Hs Code.:
DSSTox Substance ID:DTXSID60479359
Wikidata:Q82313354

Synonyms:Methanone, [3-iodo-4-(1-pyrrolidinyl)phenyl]phenyl-;834895-51-1;DTXSID60479359

Suppliers and Price of Methanone, [3-iodo-4-(1-pyrrolidinyl)phenyl]phenyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Methanone, [3-iodo-4-(1-pyrrolidinyl)phenyl]phenyl-

Chemical Property:

XLogP3:4.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:377.02766
Heavy Atom Count:20
Complexity:334

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CCN(C1)C2=C(C=C(C=C2)C(=O)C3=CC=CC=C3)I

Technology Process of Methanone, [3-iodo-4-(1-pyrrolidinyl)phenyl]phenyl-

There total 4 articles about Methanone, [3-iodo-4-(1-pyrrolidinyl)phenyl]phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 834895-49-7
4-chloro-3-iodobenzophenone

: 123-75-1
pyrrolidine

: 834895-51-1
3-iodo-4-pyrrolidinobenzophenone

Guidance literature:: Heating;
DOI:10.1016/j.tet.2004.10.069

Reference yield:

: 2840-28-0
3-amino-4-chloro-benzoic acid

: 834895-51-1
3-iodo-4-pyrrolidinobenzophenone

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium nitrite; HCl / H₂O / 5 h / 0 °C

1.2: 72 percent / KI / H₂O / 0.17 h / 90 °C

2.1: thionyl chloride; N,N-dimethylformamide / 2 h / Heating

3.1: AlCl₃ / 1 h / Heating

4.1: 49 percent / Heating

With hydrogenchloride; aluminium trichloride; thionyl chloride; N,N-dimethyl-formamide; sodium nitrite; In water; 3.1: Friedel-Crafts acylation;
DOI:10.1016/j.tet.2004.10.069

Reference yield:

: 42860-04-8
4-chloro-3-iodobenzoic acid

: 834895-51-1
3-iodo-4-pyrrolidinobenzophenone

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride; N,N-dimethylformamide / 2 h / Heating

2: AlCl₃ / 1 h / Heating

3: 49 percent / Heating

With aluminium trichloride; thionyl chloride; N,N-dimethyl-formamide; 2: Friedel-Crafts acylation;
DOI:10.1016/j.tet.2004.10.069