2,3,3,3-Tetrafluoro-1-(2-hydroxyphenyl)propan-1-one

Base Information

• Chemical Name: 2,3,3,3-Tetrafluoro-1-(2-hydroxyphenyl)propan-1-one
• CAS No.: 83505-20-8
• Molecular Formula: C9H6F4O2
• Molecular Weight: 222.139
• DSSTox Substance ID: DTXSID20511567

Synonyms:83505-20-8;2,3,3,3-Tetrafluoro-1-(2-hydroxyphenyl)propan-1-one;o-hydroxy-2,3,3,3-tetrafluoropropiophenone;1-Propanone, 2,3,3,3-tetrafluoro-1-(2-hydroxyphenyl)-;DTXSID20511567

Chemical Property of 2,3,3,3-Tetrafluoro-1-(2-hydroxyphenyl)propan-1-one

Chemical Property:

• XLogP3: 3.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 222.03039208
• Heavy Atom Count: 15
• Complexity: 239

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(=O)C(C(F)(F)F)F)O

Technology Process of 2,3,3,3-Tetrafluoro-1-(2-hydroxyphenyl)propan-1-one

There total 2 articles about 2,3,3,3-Tetrafluoro-1-(2-hydroxyphenyl)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1-(o-methoxyphenyl)pentafluoropropene → o-Hydroxy-2,3,3,3-tetrafluoropropiophenone (83505-20-8)

Guidance literature:

With hydrogen bromide; In acetic acid; at 140 ℃; for 30h;

DOI:10.1016/S0022-1139(00)82284-8

Reference yield: 22.0%

1-(o-methoxyphenyl)pentafluoropropene → o-Hydroxy-2,3,3,3-tetrafluoropropiophenone (83505-20-8) + o-methoxy-2,3,3,3-tetrafluoropropiophenone (83505-21-9)

Guidance literature:

With hydrogen bromide; In acetic acid; at 100 ℃; for 36h;

DOI:10.1016/S0022-1139(00)82284-8

Reference yield: 71.0%

o-Hydroxy-2,3,3,3-tetrafluoropropiophenone (83505-20-8) + methylamine (74-89-5) → 3-Fluoro-4-hydroxy-2-(N-methylimino)-coumarin (86606-09-9) + Methylammonium o-(2,3,3,3-tetrafluoropropanoyl)-phenolate (86606-10-2)

Guidance literature:

In water;

DOI:10.1055/s-1983-30351

Downstream raw materials:

3-Fluoro-4-hydroxy-2-(N-methylimino)-coumarin

Methylammonium o-(2,3,3,3-tetrafluoropropanoyl)-phenolate

Refernces

SYNTHESIS AND INTRAMOLECULAR CYCLISATION OF ortho-HYDROXY-2,3,3,3-TETRAFLUOROPROPIOPHENONE. FORMATION OF 3-FLUORO-4-HYDROXYCOUMARIN

10.1016/S0022-1139(00)82284-8

The research focuses on the synthesis and intramolecular cyclisation of ortho-hydroxy-2,3,3,3-tetrafluoropropiophenone. The study begins with the acidic hydrolysis of l-(o-methoxyphenyl)pentafluoropropene, which yields o-hydroxy-2,3,3,3-tetrafluoropropiophenone and o-methoxy-2,3,3,3-tetrafluoropropiophenone. When treated with aqueous potassium hydroxide or methanolic sodium methoxide, o-hydroxy-2,3,3,3-tetrafluoropropiophenone forms 3-fluoro-4-hydroxycoumarin. The structure of this compound is confirmed through spectral analysis and chemical reactions. Key chemicals involved in the research include l-(o-methoxyphenyl)pentafluoropropene, hydrobromic acid, acetic acid, potassium hydroxide, sodium methoxide, and methanol. The study also explores the cyclisation mechanism and the formation of various intermediates and products, providing insights into the defluorination process and the stability of the resulting compounds.

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 83505-20-8 1-Propanone, 2,3,3,3-tetrafluoro-1-(2-hydroxyphenyl)-

Send

Send

Metric Ton KG G Pound L ML

Send

Send