2-Iodo-1-methyl-1H-imidazole

Base Information

• Chemical Name: 2-Iodo-1-methyl-1H-imidazole
• CAS No.: 37067-95-1
• Molecular Formula: C4H5IN2
• Molecular Weight: 208.002
• Hs Code.: 2933290090
• Mol file: 37067-95-1.mol

Synonyms:1-Methyl-2-iodoimidazole;2-Iodo-1-methylimidazole;NSC 347482;

Chemical Property of 2-Iodo-1-methyl-1H-imidazole

Chemical Property:

• Vapor Pressure: 0.0103mmHg at 25°C
• Melting Point: 87 °C
• Refractive Index: 1.681
• Boiling Point: 263.4 °C at 760 mmHg
• PKA: 4.17±0.25(Predicted)
• Flash Point: 113.1 °C
• PSA: 17.82000
• Density: 2.076 g/cm³
• LogP: 1.02470
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive.: Light Sensitive

Purity/Quality:

99% ^*data from raw suppliers

2-Iodo-1-methyl-1H-imidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi, Xn
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22-41-37/38
• Safety Statements: 26-36/37/39-22-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Iodo-1-methyl-1H-imidazole

There total 3 articles about 2-Iodo-1-methyl-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-methyl-1H-imidazole (616-47-7) → 2-iodo-1-methyl-1H-imidazole (37067-95-1)

Guidance literature:

1-methyl-1H-imidazole; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 3h; Inert atmosphere;

With iodine; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol501259q

Reference yield: 46.0%

1-methyl-1H-imidazole (616-47-7) → 2-iodo-1-methyl-1H-imidazole (37067-95-1) + 2,5-diiodo-1-methyl-1H-imidazole (86026-81-5)

Guidance literature:

With 1-iodo-2,2,3,3,4,4,5,5,5-nonafluorobutane; sodium t-butanolate; In toluene; at 20 ℃; for 3h;

DOI:10.1039/c7ob03081a

Reference yield:

→ 2-iodo-1-methyl-1H-imidazole (37067-95-1)

Guidance literature:

N-Methylimidazol + Butyllithium + Jod.;

DOI:10.1007/BF00857821

upstream raw materials:

1-methyl-1H-imidazole

Downstream raw materials:

N-methyl-2-phenyl-1H-imidazole

2-(2-methoxybenzyl)-1-methylimidazole

2-(3,5-di-tert-butyl-2-methoxybenzyl)-1-methylimidazole

2-benzyl-1-methyl-1H-imidazole

Refernces

• 1、 Holthoff, Jana M.,Engelage, Elric,Kowsari, Alexander B.,Huber, Stefan M.,Weiss, Robert. "Noble Metal Corrosion: Halogen Bonded Iodocarbenium Iodides Dissolve Elemental Gold—Direct Access to Gold–Carbene Complexes". . p. 7480 - 7484. Retrieved 2019.
• 2、 Iseki, Shuta,Kishida, Sakura,Nonomura, Kohei,Ogata, Daiji,Yuasa, Junpei. "Zinc-Ion-Stabilized Charge-Transfer Interactions Drive Self-Complementary or Complementary Molecular Recognition". supporting information. p. 15842 - 15851. Retrieved 2020/10/18.