106787-27-3

Basic information

• Product Name: Phosphonic acid, (aminophenylmethyl)-, diphenyl ester, hydrobromide
• CAS NO: 106787-27-3
• Molecular Formula: C19H18NO3P.BrH
• Molecular Weight: 420.243
• Mol File: 106787-27-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Phosphonic acid, (aminophenylmethyl)-, diphenyl ester, hydrobromide(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonic acid, (aminophenylmethyl)-, diphenyl ester, hydrobromide(106787-27-3)
• EPA Substance Registry System: Phosphonic acid, (aminophenylmethyl)-, diphenyl ester, hydrobromide(106787-27-3)

Safety Data

• Hazardous Substances Data: 106787-27-3(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 101-02-0 triphenyl phosphite 
• 4712-55-4 diphenyl hydrogen phosphite 
• 110814-36-3 Diphenyl α-(diethoxythiophosphinylamino)-benzylphosphonate 

Downstream Products

• 84044-04-2 diphenyl [1-(1-amino)benzyl]phosphonate 
• 1403781-79-2 diphenyl (isothiocyanato(phenyl)methyl)phosphonate 
• 901773-70-4 (formylamino-phenyl-methyl)-phosphonic acid diphenyl ester 
• 254982-95-1 (isocyanato-phenyl-methyl)-phosphonic acid diphenyl ester 

Relevant articles and documents

A Suite of Activity-Based Probes to Dissect the KLK Activome in Drug-Resistant Prostate Cancer

Kallikrein-related peptidases (KLKs) are a family of secreted serine proteases, which form a network (the KLK activome) with an important role in proteolysis and signaling. In prostate cancer (PCa), increased KLK activity promotes tumor growth and metastasis through multiple biochemical pathways, and specific quantification and tracking of changes in the KLK activome could contribute to validation of KLKs as potential drug targets. Herein we report a technology platform based on novel activity-based probes (ABPs) and inhibitors enabling simultaneous orthogonal analysis of KLK2, KLK3, and KLK14 activity in hormone-responsive PCa cell lines and tumor homogenates. Importantly, we identifed a significant decoupling of KLK activity and abundance and suggest that KLK proteolysis should be considered as an additional parameter, along with the PSA blood test, for accurate PCa diagnosis and monitoring. Using selective inhibitors and multiplexed fluorescent activity-based protein profiling (ABPP), we dissect the KLK activome in PCa cells and show that increased KLK14 activity leads to a migratory phenotype. Furthermore, using biotinylated ABPs, we show that active KLK molecules are secreted into the bone microenvironment by PCa cells following stimulation by osteoblasts suggesting KLK-mediated signaling mechanisms could contribute to PCa metastasis to bone. Together our findings show that ABPP is a powerful approach to dissect dysregulation of the KLK activome as a promising and previously underappreciated therapeutic target in advanced PCa.

Synthesis of isocyanide derivatives of α-aminoalkylphosphonate diphenyl esters

This letter describes the first example of the synthesis of isocyanide derivatives of α-aminoalkylphosphonate diphenyl esters. This method produces the title compounds in high purity and in very good yields. It also permits the generation of an α-aminopho

Studies on organophosphorus compounds; XLVI. A facile and direct route to dialkyl 1-(benzyloxycarbonylamino)alkylphosphonates and dialkyl or diphenyl α-(benzyloxy-carbonylamino)benzylphosphonates

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