Diethyl {[4-(benzyloxy)phenyl]methyl}propanedioate

Base Information

Chemical Name:Diethyl {[4-(benzyloxy)phenyl]methyl}propanedioate
CAS No.:84184-50-9
Molecular Formula:C21H24O5
Molecular Weight:356.419
Hs Code.:
DSSTox Substance ID:DTXSID40567107
Wikidata:Q82452888

Synonyms:84184-50-9;Diethyl {[4-(benzyloxy)phenyl]methyl}propanedioate;SCHEMBL9493387;DTXSID40567107

Suppliers and Price of Diethyl {[4-(benzyloxy)phenyl]methyl}propanedioate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Diethyl {[4-(benzyloxy)phenyl]methyl}propanedioate

Chemical Property:

XLogP3:4.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:11
Exact Mass:356.16237386
Heavy Atom Count:26
Complexity:404

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C(CC1=CC=C(C=C1)OCC2=CC=CC=C2)C(=O)OCC

Technology Process of Diethyl {[4-(benzyloxy)phenyl]methyl}propanedioate

There total 6 articles about Diethyl {[4-(benzyloxy)phenyl]methyl}propanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-39-0
benzyl bromide

: 77094-90-7
3-(4-hydroxyphenyl)-2-ethoxycarbonyl-propionic acid ethyl ester

: 129673-18-3
[p-(benzyloxy)benzyl] malonic acid, monoethyl ester

: 84184-50-9
diethyl 2-(4-benzyloxybenzyl)malonate

Guidance literature:: In sodium hydroxide; ethanol;

Reference yield:

: 836-43-1
4-benzyloxybenzyl alcohol

: 84184-50-9
diethyl 2-(4-benzyloxybenzyl)malonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 93 percent / thionyl chloride / CH₂Cl₂ / 3 h / 0 °C

2.1: sodium hydride / dimethylformamide / 0.5 h / 20 °C

2.2: 98 percent / dimethylformamide / 3 h

With thionyl chloride; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.10.051