77094-90-7Relevant academic research and scientific papers
Toll-like receptor 2 antagonists. Part 1: Preliminary SAR investigation of novel synthetic phospholipids
Spyvee, Mark R.,Zhang, Huiming,Hawkins, Lynn D.,Chow, Jesse C.
, p. 5494 - 5498 (2008/09/21)
Novel synthetic phospholipid compound 1 was discovered to be an antagonist of human toll-like receptor 2 (TLR2) signaling. In a preliminary SAR campaign we synthesized several analogues of 1 and found that considerable structural changes could be made wit
The β-glucuronyl-based prodrug strategy allows for its application on β-glucuronyl-platinum conjugates
Tromp, Reynier A.,Van Boom, Stella S.G.E.,Timmers, C. Marco,Van Zutphen, Steven,Van Der Marel, Gijsbert A.,Overkleeft, Herman S.,Van Boom, Jacques H.,Reedijk, Jan
, p. 4273 - 4276 (2007/10/03)
The use of platinum drugs in antitumour therapy is well established. An important drawback of these chemotherapeutics is the lack of selectivity for tumour cells, usually resulting in severe toxic side effects. A glucuronyl-platinum conjugate was designed and synthesised to test the compatibility of platinum compounds with β-glucuronidase-based prodrug therapy. Instantaneous cleavage of the β-glucuronic bond in the glucuronyl-platinum conjugate was observed upon addition of β-glucuronidase resulting in PtII(dach)(4-hydroxybenzylmalonate) and glucuronic acid.
Aminobenzoic and aminocyclohexanecarboylic acid compounds, compositions, and their method of use
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, (2008/06/13)
Compounds of the formula inhibit the action of neutral endopeptidase. As a result, such compounds produce diuresis, natriuresis, and lower blood pressure as well as being useful in the treatment of congestive heart failure, relieving pain, and diarrhea when administered to a mammalian host.
Malonic acid derivatives and methods for their synthesis
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, (2008/06/13)
The present invention refers to a new class of malonic acid derivatives of general formula I STR1 wherein R1 and R2, each independently, represent hydrogen or a carboxyl protecting group, and the residue R corresponds to the side-cha
REACTIVITY OF NEW PRECURSORS OF QUINONE METHIDES
Loubinoux, Bernard,Miazimbakana, Joseph,Gerardin, Philippe
, p. 1939 - 1942 (2007/10/02)
The azidomethylene protecting group allows the synthesis of unstable phenolic compounds which are used as quinone methide precursors in the alkylations of alcohols, phenols, azide, thiophenol, amines, enols and enolates.
