Adenosine, 2',3'-O-(1-methylethylidene)-5'-thio-, 5'-acetate

Base Information

Chemical Name:Adenosine, 2',3'-O-(1-methylethylidene)-5'-thio-, 5'-acetate
CAS No.:84365-04-8
Molecular Formula:C15H19N5O4S
Molecular Weight:365.413
Hs Code.:

Synonyms:S-(((3aS,4S,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl) ethanethioate;5'-deoxy-5'-acetylthio-2',3'-O-isopropylideneadenosine;5'-acetylthio-2',3'-O-isopropylidene-5'-deoxyadenosine;5'-acetylthio-2',3'-O-isopropylidene-adenosine;5'-acetylthio-5'-deoxy-2',3'-O-isopropylideneadenosine;

Suppliers and Price of Adenosine, 2',3'-O-(1-methylethylidene)-5'-thio-, 5'-acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2'',?3''-?O-?(1-?Methylethylidene)?-?5''-?thio-?adenosine5''-?Acetate
100mg
$ 725.00

TRC
2'',?3''-?O-?(1-?Methylethylidene)?-?5''-?thio-?adenosine5''-?Acetate
50mg
$ 375.00

Total 2 raw suppliers

Chemical Property of Adenosine, 2',3'-O-(1-methylethylidene)-5'-thio-, 5'-acetate

Chemical Property:

Boiling Point:591.3±60.0 °C(Predicted)
PSA：139.68000
Density:1.69±0.1 g/cm3(Predicted)
LogP:1.68690

Purity/Quality:

97% ^*data from raw suppliers

2'',?3''-?O-?(1-?Methylethylidene)?-?5''-?thio-?adenosine5''-?Acetate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 2'',?3''-?O-?(1-?Methylethylidene)?-?5''-?thio-?adenosine 5''-?Acetate is an intermediate in synthesizing Decarboxylated S-Adenosylmethionine Sulfate Salt (D222000), a substrate that is involved in the biosynthesis of polyamines including spermidine, spermine, and thermospermine.

Technology Process of Adenosine, 2',3'-O-(1-methylethylidene)-5'-thio-, 5'-acetate

There total 8 articles about Adenosine, 2',3'-O-(1-methylethylidene)-5'-thio-, 5'-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 362-75-4
2',3'-isopropylidene adenosine

: 507-09-5
tiolacetic acid

: 84365-04-8
5'-acetylthio-5'-deoxy-2',3'-O-isopropylidene adenosine

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; Inert atmosphere;
DOI:10.1021/acs.jmedchem.0c01475

Reference yield: 95.0%

: 24514-56-5
9-((3aR,4R,6S,6aS)-6-(chloromethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-amine

: 84365-04-8
5'-acetylthio-5'-deoxy-2',3'-O-isopropylidene adenosine

Guidance literature:: In N,N-dimethyl-formamide; at 85 ℃;

Reference yield:

: 58-61-7
adenosine

: 84365-04-8
5'-acetylthio-5'-deoxy-2',3'-O-isopropylidene adenosine

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride; pyridine / acetonitrile / 0 - 5 °C

1.2: 0.5 h / 20 °C

2.1: toluene-4-sulfonic acid; orthoformic acid triethyl ester / water / 1 h

2.2: pH 8

3.1: N,N-dimethyl-formamide / 85 °C

With pyridine; thionyl chloride; toluene-4-sulfonic acid; orthoformic acid triethyl ester; In water; N,N-dimethyl-formamide; acetonitrile;