1H-Isoindole-1,3(2H)-dione, 2-((3-(3-((diethylamino)methyl)-4-hydroxyphenyl)-3,4-dihydro-6-iodo-4-oxo-2-quinazolinyl)methyl)-

Base Information

Chemical Name:1H-Isoindole-1,3(2H)-dione, 2-((3-(3-((diethylamino)methyl)-4-hydroxyphenyl)-3,4-dihydro-6-iodo-4-oxo-2-quinazolinyl)methyl)-
CAS No.:134700-43-9
Molecular Formula:C28H25IN4O4
Molecular Weight:608.427
Hs Code.:
DSSTox Substance ID:DTXSID50158883
Wikidata:Q83027174
Mol file:134700-43-9.mol

Synonyms:BRN 4773745;1H-Isoindole-1,3(2H)-dione, 2-((3-(3-((diethylamino)methyl)-4-hydroxyphenyl)-3,4-dihydro-6-iodo-4-oxo-2-quinazolinyl)methyl)-;134700-43-9;C28H25IN4O4;DTXSID50158883;C28-H25-I-N4-O4;LS-84551

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Chemical Property of 1H-Isoindole-1,3(2H)-dione, 2-((3-(3-((diethylamino)methyl)-4-hydroxyphenyl)-3,4-dihydro-6-iodo-4-oxo-2-quinazolinyl)methyl)-

Chemical Property:

Vapor Pressure:1.97E-22mmHg at 25°C
Boiling Point:736.6°Cat760mmHg
Flash Point:399.3°C
Density:1.59g/cm³
XLogP3:4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:608.09205
Heavy Atom Count:37
Complexity:900

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN(CC)CC1=C(C=CC(=C1)N2C(=NC3=C(C2=O)C=C(C=C3)I)CN4C(=O)C5=CC=CC=C5C4=O)O

Technology Process of 1H-Isoindole-1,3(2H)-dione, 2-((3-(3-((diethylamino)methyl)-4-hydroxyphenyl)-3,4-dihydro-6-iodo-4-oxo-2-quinazolinyl)methyl)-

There total 4 articles about 1H-Isoindole-1,3(2H)-dione, 2-((3-(3-((diethylamino)methyl)-4-hydroxyphenyl)-3,4-dihydro-6-iodo-4-oxo-2-quinazolinyl)methyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6780-38-7
N-phthaloylglycine chloride

: 134700-43-9
2-[3-(3-Diethylaminomethyl-4-hydroxy-phenyl)-6-iodo-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl]-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 1) 0 to 5 deg C, 1h, 2) RT, overnight

2: 75 percent / pyridine / Heating

3: 1) EtOH, 1h, reflux, 2) 12h, reflux

With pyridine;

Reference yield:

: 134700-31-5
2-(6-Iodo-4-oxo-4H-benzo[d][1,3]oxazin-2-ylmethyl)-isoindole-1,3-dione

: 134700-43-9
2-[3-(3-Diethylaminomethyl-4-hydroxy-phenyl)-6-iodo-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl]-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / pyridine / Heating

2: 1) EtOH, 1h, reflux, 2) 12h, reflux

With pyridine;

Reference yield:

: 5326-47-6
2-amino-5-iodobenzoic acid

: 134700-43-9
2-[3-(3-Diethylaminomethyl-4-hydroxy-phenyl)-6-iodo-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl]-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 1) 0 to 5 deg C, 1h, 2) RT, overnight

2: 75 percent / pyridine / Heating

3: 1) EtOH, 1h, reflux, 2) 12h, reflux

With pyridine;