N-(2-Hydroxypropyl)morpholine

Base Information

• Chemical Name: N-(2-Hydroxypropyl)morpholine
• CAS No.: 2109-66-2
• Molecular Formula: C7H15NO2
• Molecular Weight: 145.202
• Hs Code.: 2934999090
• European Community (EC) Number: 218-298-8
• NSC Number: 61987
• DSSTox Substance ID: DTXSID80883797
• Nikkaji Number: J208.578J
• Mol file: 2109-66-2.mol

Synonyms:2109-66-2;N-(2-Hydroxypropyl)morpholine;1-morpholin-4-ylpropan-2-ol;1-morpholinopropan-2-ol;1-(morpholin-4-yl)propan-2-ol;4-(2-Hydroxypropyl)morpholine;1-Morpholino-2-propanol;1-(4-Morpholino)-2-propanol;4-Morpholineethanol, alpha-methyl-;4-Morpholineethanol, .alpha.-methyl-;1-(4-morpholinyl)-2-propanol;1-morpholin-4-yl-propan-2-ol;4-Morpholineethanol, a-methyl-;4-Morphlineethanol;NSC61987;1-(morpholino)propan-2-ol;1-N-Morpholino-2-propanol;4-Morpholineethanol,a-methyl-;SCHEMBL452906;N-(2-hydroxypropyl)-morpholine;Alpha-methyl-4-morpholineethanol;DTXSID80883797;.alpha.-Methyl-4-morpholineethanol;N-(.beta.-Hydroxypropyl)morpholine;EINECS 218-298-8;MFCD00023378;NSC 61987;NSC-61987;AKOS005206836;AT23627;FS-4675;CS-0096282;FT-0605759;H0437;EN300-124762;W-109751

Chemical Property of N-(2-Hydroxypropyl)morpholine

Chemical Property:

• Vapor Pressure: 0.0102mmHg at 25°C
• Refractive Index: 1.4620
• Boiling Point: 233.6 °C at 760 mmHg
• PKA: 14.95±0.20(Predicted)
• Flash Point: 95.1 °C
• PSA: 32.70000
• Density: 1.033 g/cm³
• LogP: -0.36270
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 145.110278721
• Heavy Atom Count: 10
• Complexity: 91.6

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-(2-Hydroxypropyl)morpholine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/38:Irritating to eyes and skin.
• Hazard Codes: R36/38:Irritating to eyes and skin.
• Statements: 36/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(CN1CCOCC1)O
• Uses: N-(2-Hydroxypropyl)morpholine is used as a brass corrosion inhibitor. Also used in the synthesis of mGluR1 ligands as pyrimidin-4-ylamines.

Technology Process of N-(2-Hydroxypropyl)morpholine

There total 9 articles about N-(2-Hydroxypropyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

morpholine (110-91-8,99108-56-2) + methyloxirane (75-56-9,16033-71-9) → 4-(2-hydroxypropyl)morpholine (2109-66-2)

Guidance literature:

In water; at 90 ℃; for 9h; regioselective reaction;

DOI:10.1134/S1070363210090173

Reference yield:

morpholine (110-91-8,99108-56-2) + methyloxirane (75-56-9,16033-71-9) → beta-methyl morpholinoethanol (69296-06-6) + 4-(2-hydroxypropyl)morpholine (2109-66-2)

Guidance literature:

In methanol; at 45 ℃; for 3h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1016/S0022-1139(00)80506-0

Reference yield:

3-morpholinoacetone (6704-35-4) → 4-(2-hydroxypropyl)morpholine (2109-66-2)

Guidance literature:

With methanol; sodium tetrahydroborate; at 0 - 20 ℃; for 12h;

upstream raw materials:

morpholine

1-Chloro-2-propanol

3-amino-2-propanol

3-oxa-1,5-dichloropentane

Downstream raw materials:

4-(2-chloropropyl)morpholine hydrochloride

(+/-)-4-[2-(2,4-dichlorophenoxy)propyl]morpholine

(+/-)-4-[2-(2,3-dichlorophenoxy)propyl]morpholine

(+/-)-4-[2-(2,4-dichlorophenoxy)propyl]morpholine oxalate