N-[4-(Ethoxycarbonylamino)phenyl]carbamic acid ethyl ester

Base Information

• Chemical Name: N-[4-(Ethoxycarbonylamino)phenyl]carbamic acid ethyl ester
• CAS No.: 5466-93-3
• Molecular Formula: C12H16N2O4
• Molecular Weight: 252.27
• Hs Code.: 2924299090
• Mol file: 5466-93-3.mol

Synonyms:N,N'-p-phenylene-bis-carbamic acid diethyl ester;p-Phenylenediurethane;N,N'-p-Phenylen-bis-carbamidsaeure-diaethylester;diethyl 1,4-phenylenebiscarbamate;diethyl 1,4-phenylenediamine-N,N'-dicarboxylate;N,N-diethoxycarbonyl-1,4-phenylenediamine;diethyl N,N'-1,4-phenylenedicarbamate;

Chemical Property of N-[4-(Ethoxycarbonylamino)phenyl]carbamic acid ethyl ester

Chemical Property:

• Vapor Pressure: 0.00122mmHg at 25°C
• Melting Point: 195-196 °C
• Boiling Point: 299°Cat760mmHg
• PKA: 13.02±0.70(Predicted)
• Flash Point: 134.7°C
• PSA: 76.66000
• Density: 1.252g/cm³
• LogP: 2.96940

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-[4-(Ethoxycarbonylamino)phenyl]carbamic acid ethyl ester

There total 13 articles about N-[4-(Ethoxycarbonylamino)phenyl]carbamic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

chloroformic acid ethyl ester (541-41-3) + 1,4-phenylenediamine (106-50-3) → diethyl 1,4-phenylenediamine-N,N'-dicarboxylate (5466-93-3)

Guidance literature:

With TEA; In tetrahydrofuran; for 1h; Heating;

DOI:10.1016/j.tet.2006.09.103

Reference yield: 95.0%

→ diethyl 1,4-phenylenediamine-N,N'-dicarboxylate (5466-93-3)

Guidance literature:

Reference yield: 82.0%

4-methoxy-N,N-dimethylanilne (701-56-4) + N,N'-bisethoxycarbonyl-p-benzoquinone diimine (116015-90-8) → [4-(Ethoxycarbonyl-{[(4-methoxy-phenyl)-methyl-amino]-methyl}-amino)-phenyl]-carbamic acid ethyl ester (116015-94-2) + diethyl 1,4-phenylenediamine-N,N'-dicarboxylate (5466-93-3)

Guidance literature:

In benzene; for 48h; Ambient temperature;

DOI:10.1246/cl.1988.51

upstream raw materials:

chloroformic acid ethyl ester

1,4-phenylenediamine

ethanol

1,4-diisocyanatobenzene

Downstream raw materials:

1,4-diisocyanatobenzene

ethyl N-{[2-(phthalimidomethyl)-4-ethoxycarbonylamino]phenyl}carbamate

6-amino-quinazoline

diethyl N,N'-(2-nitro-1,4-phenylene)dicarbamate