5-Phenyl-1,3,4-thiadiazole-2-acetic acid

Base Information

Chemical Name:5-Phenyl-1,3,4-thiadiazole-2-acetic acid
CAS No.:85730-46-7
Molecular Formula:C10H8N2O2S
Molecular Weight:220.252
Hs Code.:
DSSTox Substance ID:DTXSID201274381

Synonyms:5-Phenyl-1,3,4-thiadiazole-2-acetic acid;85730-46-7;DTXSID201274381

Suppliers and Price of 5-Phenyl-1,3,4-thiadiazole-2-acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-Phenyl-1,3,4-thiadiazole-2-acetic acid

Chemical Property:

XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:220.03064868
Heavy Atom Count:15
Complexity:232

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=NN=C(S2)CC(=O)O

Technology Process of 5-Phenyl-1,3,4-thiadiazole-2-acetic acid

There total 4 articles about 5-Phenyl-1,3,4-thiadiazole-2-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 85730-47-8
diethyl 2-(5-phenyl-1,3,4-thiadiazol-2-yl)malonate

: 85730-46-7
2-(5-phenyl-1,3,4-thiadiazol-2-yl)acetic acid

Guidance literature:: With potassium carbonate; In ethanol; for 8h; Heating;
DOI:10.1002/jhet.5570200117

Reference yield:

: 53645-95-7
2-bromo-5-phenyl-1,3,4-thiadiazole

: 85730-46-7
2-(5-phenyl-1,3,4-thiadiazol-2-yl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 44 percent / EtONa / ethanol

2: 89 percent / K₂CO₃ / aq. ethanol / 8 h / Heating

With sodium ethanolate; potassium carbonate; In ethanol;
DOI:10.1002/jhet.5570200117

Reference yield:

: 2002-03-1
2-amino-5-phenyl-1,3,4-thiadiazole

: 85730-46-7
2-(5-phenyl-1,3,4-thiadiazol-2-yl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1) 48percent HBr, Br₂, 2) NaNO₂ / 2) water, 0 deg C, 30 min

2: 44 percent / EtONa / ethanol

3: 89 percent / K₂CO₃ / aq. ethanol / 8 h / Heating

With hydrogen bromide; bromine; sodium ethanolate; potassium carbonate; sodium nitrite; In ethanol;
DOI:10.1002/jhet.5570200117