(5-Phenyl-[1,3,4]thiadiazol-2-yl)-(2,2,2-trichloro-ethoxycarbonylamino)-acetic acid ethyl ester

Base Information

Chemical Name:(5-Phenyl-[1,3,4]thiadiazol-2-yl)-(2,2,2-trichloro-ethoxycarbonylamino)-acetic acid ethyl ester
CAS No.:85730-50-3
Molecular Formula:C₁₅H₁₄Cl₃N₃O₄S
Molecular Weight:438.719
Hs Code.:

Synonyms:(5-Phenyl-[1,3,4]thiadiazol-2-yl)-(2,2,2-trichloro-ethoxycarbonylamino)-acetic acid ethyl ester

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Chemical Property of (5-Phenyl-[1,3,4]thiadiazol-2-yl)-(2,2,2-trichloro-ethoxycarbonylamino)-acetic acid ethyl ester

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Technology Process of (5-Phenyl-[1,3,4]thiadiazol-2-yl)-(2,2,2-trichloro-ethoxycarbonylamino)-acetic acid ethyl ester

There total 8 articles about (5-Phenyl-[1,3,4]thiadiazol-2-yl)-(2,2,2-trichloro-ethoxycarbonylamino)-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 85730-49-0
ethyl α-amino-2-phenyl-1,3,4-thiadiazol-5-ylacetate

: 17341-93-4
2,2,2-Trichloroethyl chloroformate

: 85730-50-3
(5-Phenyl-[1,3,4]thiadiazol-2-yl)-(2,2,2-trichloro-ethoxycarbonylamino)-acetic acid ethyl ester

Guidance literature:: With pyridine; In tetrahydrofuran; at -20 ℃; for 3h;
DOI:10.1002/jhet.5570200117

Reference yield:

: 1456-72-0
2-methyl-5-phenyl-1,3,4-thiadiazole

: 85730-50-3
(5-Phenyl-[1,3,4]thiadiazol-2-yl)-(2,2,2-trichloro-ethoxycarbonylamino)-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1) n-butyllithium / 1) THF, 2) -70 deg C

2: 85 percent / K₂CO₃ / dimethylformamide / Ambient temperature

3: 78 percent / NaNO₂, acetic acid / ethanol / 0.5 h

4: 1.2 g / Zn, formic acid / tetrahydrofuran; H₂O / 1 h / 0 - 5 °C

5: 94 percent / pyridine / tetrahydrofuran / 3 h / -20 °C

With pyridine; n-butyllithium; formic acid; potassium carbonate; acetic acid; zinc; sodium nitrite; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570200117

Reference yield:

: 53645-95-7
2-bromo-5-phenyl-1,3,4-thiadiazole

: 85730-50-3
(5-Phenyl-[1,3,4]thiadiazol-2-yl)-(2,2,2-trichloro-ethoxycarbonylamino)-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 44 percent / EtONa / ethanol

2: 89 percent / K₂CO₃ / aq. ethanol / 8 h / Heating

3: 85 percent / K₂CO₃ / dimethylformamide / Ambient temperature

4: 78 percent / NaNO₂, acetic acid / ethanol / 0.5 h

5: 1.2 g / Zn, formic acid / tetrahydrofuran; H₂O / 1 h / 0 - 5 °C

6: 94 percent / pyridine / tetrahydrofuran / 3 h / -20 °C

With pyridine; formic acid; sodium ethanolate; potassium carbonate; acetic acid; zinc; sodium nitrite; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570200117