2-chloro-N-(2-methoxy-5-methylphenyl)acetamide

Base Information

• Chemical Name: 2-chloro-N-(2-methoxy-5-methylphenyl)acetamide
• CAS No.: 85817-61-4
• Molecular Formula: C₁₀H₁₂ClNO₂
• Molecular Weight: 213.664
• Hs Code.: 2924299090
• European Community (EC) Number: 661-132-8
• DSSTox Substance ID: DTXSID30353157
• Wikidata: Q82130616
• Mol file: 85817-61-4.mol

Synonyms:2-chloro-N-(2-methoxy-5-methylphenyl)acetamide;85817-61-4;N1-(2-methoxy-5-methylphenyl)-2-chloroacetamide;SCHEMBL10684407;DTXSID30353157;ZVVBFKIUBBHWEV-UHFFFAOYSA-N;MFCD00095382;STK205300;AKOS000265099;JS-2984;N-(Chloroacetyl)-2-methoxy-5-methylaniline;BB 0243206;CS-0218638;FT-0706080;EN300-01585;10.14272/ZVVBFKIUBBHWEV-UHFFFAOYSA-N;2-CHLORO-2'-METHOXY-5'-METHYLACETANILIDE;doi:10.14272/ZVVBFKIUBBHWEV-UHFFFAOYSA-N;2-Chloro-N-(2-methoxy-5-methyl-phenyl)-acet amide;Z56896326

Chemical Property of 2-chloro-N-(2-methoxy-5-methylphenyl)acetamide

Chemical Property:

• PSA: 38.33000
• LogP: 2.25390
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 213.0556563
• Heavy Atom Count: 14
• Complexity: 199

Purity/Quality:

98%min ^*data from raw suppliers

2-Chloro-N-(2-methoxy-5-methylphenyl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C=C1)OC)NC(=O)CCl

Technology Process of 2-chloro-N-(2-methoxy-5-methylphenyl)acetamide

There total 3 articles about 2-chloro-N-(2-methoxy-5-methylphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

→ 2-chloro-N-(2-methoxy-5-methylphenyl)acetamide (85817-61-4)

Guidance literature:

With sodium hydrogencarbonate; In ethyl acetate; at 0 - 20 ℃; for 1.66667h;

Reference yield: 72.6%

chloroacetyl chloride (79-04-9) + Cresidine (120-71-8) → 2-chloro-N-(2-methoxy-5-methylphenyl)acetamide (85817-61-4)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 4h;

DOI:10.1016/j.bmcl.2022.128590

Reference yield:

chloroacetyl chloride (79-04-9) + toluene (108-88-3,15644-74-3,16713-13-6) + Cresidine (120-71-8) → 2-chloro-N-(2-methoxy-5-methylphenyl)acetamide (85817-61-4)

Guidance literature:

In water;

upstream raw materials:

chloroacetyl chloride

Cresidine

toluene