Ethyl 3,5-diiodo-4-(4-methoxyphenoxy)phenylacetate

Base Information

Chemical Name:Ethyl 3,5-diiodo-4-(4-methoxyphenoxy)phenylacetate
CAS No.:85828-82-6
Molecular Formula:C17H16I2O4
Molecular Weight:538.121
Hs Code.:2918990090
European Community (EC) Number:288-610-5
DSSTox Substance ID:DTXSID10235109
Nikkaji Number:J310.877E
Wikidata:Q83116962
Mol file:85828-82-6.mol

Synonyms:85828-82-6;Ethyl 3,5-diiodo-4-(4-methoxyphenoxy)phenylacetate;EINECS 288-610-5;ethyl 2-[3,5-diiodo-4-(4-methoxyphenoxy)phenyl]acetate;3,5-Diiodo-4'-O-methyl Thyroacetic Acid Ethyl Ester;SCHEMBL6859639;Levothyroxine Sodium Impurity 8;DTXSID10235109;BCP33820;AKOS030254982;3,5-Diiodo-4-(4-methoxyphenoxy)benzeneacetic acid ethyl ester;3,5-Diiodo-4 inverted exclamation mark -O-methyl Thyroacetic Acid Ethyl Ester

Suppliers and Price of Ethyl 3,5-diiodo-4-(4-methoxyphenoxy)phenylacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3,5-Diiodo-4’-O-methylThyroaceticAcidEthylEster
100mg
$ 140.00

Medical Isotopes, Inc.
3,5-Diiodo-4??-O-methylThyroaceticAcidEthylEster
100 mg
$ 625.00

Total 6 raw suppliers

Chemical Property of Ethyl 3,5-diiodo-4-(4-methoxyphenoxy)phenylacetate

Chemical Property:

Vapor Pressure:2.35E-09mmHg at 25°C
Boiling Point:479.5°Cat760mmHg
Flash Point:243.8°C
PSA：44.76000
Density:1.808g/cm³
LogP:4.80230
Solubility.:Dichloromethane
XLogP3:4.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:537.91380
Heavy Atom Count:23
Complexity:360

Purity/Quality:

98% ^*data from raw suppliers

3,5-Diiodo-4’-O-methylThyroaceticAcidEthylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)CC1=CC(=C(C(=C1)I)OC2=CC=C(C=C2)OC)I
Uses 3,5-Diiodo-4’-O-methyl Thyroacetic Acid Ethyl Ester is a derivative of 3,5-Diiodo Thyroacetic Acid (D455140), the acetic acid analog of Thyroxine (T425601). It is a reactant in the preparation of bifunctional thyrointegrin inhibitors, thyroxine (T425601) and triiodothyronine (T795380).

Technology Process of Ethyl 3,5-diiodo-4-(4-methoxyphenoxy)phenylacetate

There total 7 articles about Ethyl 3,5-diiodo-4-(4-methoxyphenoxy)phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 101588-11-8
C₁₇H₂₀N₂O₄

: 85828-82-6
[3,5-diiodo-4-(4-methoxy-phenoxy)-phenyl]-acetic acid ethyl ester

Guidance literature:: C₁₇H₂₀N₂O₄; With sulfuric acid; acetic acid; sodium nitrite; at 0 ℃; for 1.75h;

With iodine; urea; sodium iodide; In chloroform; water; at 20 ℃; for 1h;

Reference yield:

: 83799-60-4
(4-hydroxy-3,5-dinitro-phenyl)-acetic acid ethyl ester

: 85828-82-6
[3,5-diiodo-4-(4-methoxy-phenoxy)-phenyl]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine; p-toluenesulfonyl chloride / 0.5 h / 95 - 100 °C

1.2: 2 h / 125 °C / Inert atmosphere

2.1: hydrogen / 5% Pd-CaCO3 / ethanol

3.1: sodium nitrite; sulfuric acid; acetic acid / 1.75 h / 0 °C

3.2: 1 h / 20 °C

With pyridine; sulfuric acid; hydrogen; acetic acid; p-toluenesulfonyl chloride; sodium nitrite; 5% Pd-CaCO3; In ethanol;

Reference yield:

: 861065-72-7
[4-(4-methoxy-phenoxy)-3,5-dinitro-phenyl]-acetic acid ethyl ester

: 85828-82-6
[3,5-diiodo-4-(4-methoxy-phenoxy)-phenyl]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / 5% Pd-CaCO3 / ethanol

2.1: sodium nitrite; sulfuric acid; acetic acid / 1.75 h / 0 °C

2.2: 1 h / 20 °C

With sulfuric acid; hydrogen; acetic acid; sodium nitrite; 5% Pd-CaCO3; In ethanol;