16-methylene estrone

Base Information

• Chemical Name: 16-methylene estrone
• CAS No.: 10506-73-7
• Molecular Formula: C19H22 O2
• Molecular Weight: 282.38
• Mol file: 10506-73-7.mol

Synonyms:Estrone,16-methylene- (6CI); 16-Methyleneestrone

Chemical Property of 16-methylene estrone

Chemical Property:

• Vapor Pressure: 3.42E-09mmHg at 25°C
• Boiling Point: 463°C at 760 mmHg
• Flash Point: 197°C
• PSA: 37.30000
• Density: 1.18g/cm³
• LogP: 3.98350

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 16-methylene estrone

There total 4 articles about 16-methylene estrone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

ethanol (64-17-5) + 3-O-acetyl-16-methylene-estrone (7627-93-2) → 16β-ethoxymethyl-estrone + 3-hydroxy-16-methylen-estra-1,3,5(10)-trien-17-one (10506-73-7)

Guidance literature:

With potassium hydroxide; at 0 ℃; for 0.5h;

DOI:10.1021/jm050830t

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + Estrone (53-16-7) → 3-hydroxy-16-methylen-estra-1,3,5(10)-trien-17-one (10506-73-7)

Guidance literature:

With potassium hydroxide; In ethanol; water; at 20 ℃; for 24h;

DOI:10.3390/molecules24112054

Reference yield:

estrone acetate (901-93-9) → 3-hydroxy-16-methylen-estra-1,3,5(10)-trien-17-one (10506-73-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 51 percent / dimethylamine hydrochloride / 3-methyl-butan-1-ol / 24 h / Heating

2: aq. KOH / 0.5 h / 0 °C

With potassium hydroxide; N,N-dimethylammonium chloride; In i-Amyl alcohol;

DOI:10.1021/jm050830t

upstream raw materials:

ethanol

3-O-acetyl-16-methylene-estrone

estrone acetate

formaldehyd

Downstream raw materials:

16-Methylenestradiol

Refernces

• 1、 Allan, Gillian M.,Lawrence, Harshani R.,Cornet, Josephine,Bubert, Christian,Fischer, Delphine S.,Vicker, Nigel,Smith, Andrew,Tutill, Helena J.,Purohit, Atul,Day, Joanna M.,Mahon, Mary F.,Reed, Michael J.,Potter, Barry V. L.. "Modification of estrone at the 6, 16, and 17 positions: Novel potent inhibitors of 17β-hydroxysteroid dehydrogenase type 1". . p. 1325 - 1345. Retrieved 2007/10/03.