4-(1H-IMIDAZOL-4-YLMETHYL)-CYCLOHEXYLAMINE 2HBR

Base Information

• Chemical Name: 4-(1H-IMIDAZOL-4-YLMETHYL)-CYCLOHEXYLAMINE 2HBR
• CAS No.: 869501-03-1
• Molecular Formula: 2BrH*C₁₀H₁₇N₃
• Molecular Weight: 341.089
• Mol file: 869501-03-1.mol

Synonyms:

Chemical Property of 4-(1H-IMIDAZOL-4-YLMETHYL)-CYCLOHEXYLAMINE 2HBR

Chemical Property:

• PSA: 54.70000
• LogP: 4.08620

Purity/Quality:

4-(1H-IMIDAZOL-4-YLMETHYL)CYCLOHEXYLAMINE DIHYDROBROMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(1H-IMIDAZOL-4-YLMETHYL)-CYCLOHEXYLAMINE 2HBR

There total 9 articles about 4-(1H-IMIDAZOL-4-YLMETHYL)-CYCLOHEXYLAMINE 2HBR which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclohexanedione monoethylene ketal (4746-97-8) → 4-(1H-imidazol-5-ylmethyl)cyclohexylamine dihidrobromide (869501-03-1)

Guidance literature:

Multi-step reaction with 9 steps

1.1: 95 percent / NaH / tetrahydrofuran / 6 h / 20 °C

2.1: 100 percent / H₂ / Pd/C / methanol / 4 h

3.1: 95 percent / LiAlH₄ / tetrahydrofuran / 4 h / 20 °C

4.1: 90 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 2 h / -60 - 20 °C

5.1: sodium cyanide / ethanol / 2 h

5.2: 70 percent / NH₃ / ethanol / 16 h / 90 - 110 °C

6.1: 95 percent / HCl / 0.5 h / 20 °C

7.1: 75 percent / triethylamine / CHCl₃ / 16 h / 20 °C

8.1: ammonium acetate; NaBH₄ / methanol / 16 h / 20 °C

9.1: HBr / 1 h / 20 °C

With ammonium acetate; hydrogenchloride; sodium cyanide; sodium tetrahydroborate; lithium aluminium tetrahydride; oxalyl dichloride; hydrogen bromide; hydrogen; sodium hydride; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; 1.1: Wittig reaction / 4.1: Swern oxidation;

DOI:10.1016/j.bmc.2005.09.002

Reference yield:

ethyl 1,4-dioxaspiro[4,5]dec-8-ylideneacetate (51656-91-8) → 4-(1H-imidazol-5-ylmethyl)cyclohexylamine dihidrobromide (869501-03-1)

Guidance literature:

Multi-step reaction with 8 steps

1.1: 100 percent / H₂ / Pd/C / methanol / 4 h

2.1: 95 percent / LiAlH₄ / tetrahydrofuran / 4 h / 20 °C

3.1: 90 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 2 h / -60 - 20 °C

4.1: sodium cyanide / ethanol / 2 h

4.2: 70 percent / NH₃ / ethanol / 16 h / 90 - 110 °C

5.1: 95 percent / HCl / 0.5 h / 20 °C

6.1: 75 percent / triethylamine / CHCl₃ / 16 h / 20 °C

7.1: ammonium acetate; NaBH₄ / methanol / 16 h / 20 °C

8.1: HBr / 1 h / 20 °C

With ammonium acetate; hydrogenchloride; sodium cyanide; sodium tetrahydroborate; lithium aluminium tetrahydride; oxalyl dichloride; hydrogen bromide; hydrogen; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; 3.1: Swern oxidation;

DOI:10.1016/j.bmc.2005.09.002

Reference yield:

4-(1H-imidazol-5-ylmethyl)cyclohexanone (317338-52-6) → 4-(1H-imidazol-5-ylmethyl)cyclohexylamine dihidrobromide (869501-03-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / triethylamine / CHCl₃ / 16 h / 20 °C

2: ammonium acetate; NaBH₄ / methanol / 16 h / 20 °C

3: HBr / 1 h / 20 °C

With ammonium acetate; sodium tetrahydroborate; hydrogen bromide; triethylamine; In methanol; chloroform;

DOI:10.1016/j.bmc.2005.09.002

upstream raw materials:

4-(4-aminocyclohexylmethyl)imidazole-1-carboxylic acid tert-butyl ester

4-(1H-imidazol-5-ylmethyl)cyclohexanone

5-(1,4-dioxaspiro[4.5]dec-8-ylmethyl)-1H-imidazole

4-(4-oxocyclohexylmethyl)imidazole-1-carboxylic acid tert-butyl ester

Refernces