1H-Imidazole-1-carboxylic acid, 4-[(4-oxocyclohexyl)methyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1H-Imidazole-1-carboxylic acid, 4-[(4-oxocyclohexyl)methyl]-, 1,1-dimethylethyl ester
CAS No.:869501-10-0
Molecular Formula:C15H22N2O3
Molecular Weight:278.351
Hs Code.:

Synonyms:

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Chemical Property of 1H-Imidazole-1-carboxylic acid, 4-[(4-oxocyclohexyl)methyl]-, 1,1-dimethylethyl ester

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Technology Process of 1H-Imidazole-1-carboxylic acid, 4-[(4-oxocyclohexyl)methyl]-, 1,1-dimethylethyl ester

There total 7 articles about 1H-Imidazole-1-carboxylic acid, 4-[(4-oxocyclohexyl)methyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 317338-52-6
4-(1H-imidazol-5-ylmethyl)cyclohexanone

: 24424-99-5
di-tert-butyl dicarbonate

: 869501-10-0
4-(4-oxocyclohexylmethyl)imidazole-1-carboxylic acid tert-butyl ester

Guidance literature:: With triethylamine; In chloroform; at 20 ℃; for 16h;
DOI:10.1016/j.bmc.2005.09.002

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 869501-10-0
4-(4-oxocyclohexylmethyl)imidazole-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 95 percent / NaH / tetrahydrofuran / 6 h / 20 °C

2.1: 100 percent / H₂ / Pd/C / methanol / 4 h

3.1: 95 percent / LiAlH₄ / tetrahydrofuran / 4 h / 20 °C

4.1: 90 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 2 h / -60 - 20 °C

5.1: sodium cyanide / ethanol / 2 h

5.2: 70 percent / NH₃ / ethanol / 16 h / 90 - 110 °C

6.1: 95 percent / HCl / 0.5 h / 20 °C

7.1: 75 percent / triethylamine / CHCl₃ / 16 h / 20 °C

With hydrogenchloride; sodium cyanide; lithium aluminium tetrahydride; oxalyl dichloride; hydrogen; sodium hydride; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; 1.1: Wittig reaction / 4.1: Swern oxidation;
DOI:10.1016/j.bmc.2005.09.002

Reference yield:

: 51656-91-8
ethyl 1,4-dioxaspiro[4,5]dec-8-ylideneacetate

: 869501-10-0
4-(4-oxocyclohexylmethyl)imidazole-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 100 percent / H₂ / Pd/C / methanol / 4 h

2.1: 95 percent / LiAlH₄ / tetrahydrofuran / 4 h / 20 °C

3.1: 90 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 2 h / -60 - 20 °C

4.1: sodium cyanide / ethanol / 2 h

4.2: 70 percent / NH₃ / ethanol / 16 h / 90 - 110 °C

5.1: 95 percent / HCl / 0.5 h / 20 °C

6.1: 75 percent / triethylamine / CHCl₃ / 16 h / 20 °C

With hydrogenchloride; sodium cyanide; lithium aluminium tetrahydride; oxalyl dichloride; hydrogen; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; 3.1: Swern oxidation;
DOI:10.1016/j.bmc.2005.09.002